N
Nikolay A. Krylov
Researcher at Russian Academy of Sciences
Publications - 26
Citations - 598
Nikolay A. Krylov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Lipid bilayer & Chemistry. The author has an hindex of 10, co-authored 22 publications receiving 415 citations. Previous affiliations of Nikolay A. Krylov include Moscow Institute of Physics and Technology & National Research University – Higher School of Economics.
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PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes.
TL;DR: The PLATINUM web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures and provides a number of tools for quantitative characterization of the hydrophilic match in biomolecular complexes.
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PREDDIMER: a web server for prediction of transmembrane helical dimers
Anton A. Polyansky,Anton O. Chugunov,Pavel E. Volynsky,Nikolay A. Krylov,Dmitry E. Nolde,Roman G. Efremov +5 more
TL;DR: Going beyond a single dimer conformation, the PREDDIMER web tool predicts an ensemble of possible conformations, which may be useful for explanation of a functioning of bitopic membrane proteins, e.g. receptor tyrosine kinases.
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Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Kirill D. Nadezhdin,Arthur Neuberger,Yuri A. Trofimov,Yuri A. Trofimov,Yuri A. Trofimov,Nikolay A. Krylov,Nikolay A. Krylov,Viktor Sinica,Nikita Kupko,Viktorie Vlachova,Eleonora Zakharian,Roman G. Efremov,Roman G. Efremov,Roman G. Efremov,Alexander I. Sobolevsky +14 more
TL;DR: Cryo-EM structures of the nanodisc-reconstituted wild-type mouse TRPV3 in three distinct conformations, supported by physiological recordings and molecular dynamics simulations, provide an insight for understanding the molecular mechanism of temperature sensing.
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Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans- and juxtamembrane domains
Anton O. Chugunov,Pavel E. Volynsky,Nikolay A. Krylov,Dmitry E. Nolde,Roman G. Efremov,Roman G. Efremov +5 more
TL;DR: Analysis of structural, dynamic, and hydrophobic organization of the pore domain revealed entropy growth upon TRPV1 gating, which is in line with current concepts of thermal sensitivity.
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Kalium: a database of potassium channel toxins from scorpion venom
Alexey I. Kuzmenkov,Nikolay A. Krylov,Anton O. Chugunov,Eugene V. Grishin,Alexander A. Vassilevski +4 more
TL;DR: Kalium is a manually curated database that accumulates data on potassium channel toxins purified from scorpion venom (KTx) and provides easy access to pages of other databases of interest, such as UniProt, PDB, NCBI Taxonomy Browser, and PubMed.