Roman G. Efremov

TL;DR: The spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelles was obtained by solution NMR, followed by molecular dynamics relaxation in an explicit lipid bilayer, providing an explanation for the pathogenic power of some oncogenic mutations.

TL;DR: The PLATINUM web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures and provides a number of tools for quantitative characterization of the hydrophilic match in biomolecular complexes.

TL;DR: The right-handed parallel helix-helix structure of the transmembrane domain with a hydrogen bond-rich His-Ser node in the middle of the membrane, accessibility of the node for water, and continuous hydrophilic track across the membrane suggest that the domain can provide an ion-conducting pathway through the membrane.

TL;DR: It is demonstrated that the application of the MHP-based techniques in combination with other molecular modeling tools permits significant improvement to the standard computational approaches, provides additional important insights into the intimate molecular mechanisms driving protein assembling in water and in biological membranes, and helps in the computer-aided drug discovery process.

TL;DR: In this paper, the surface-enhanced Raman spectra of water-soluble proteins (lysozyme and bovine serum albumin), dipeptides and amino acids were analysed.