Timothy V. Pyrkov

TL;DR: The PLATINUM web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures and provides a number of tools for quantitative characterization of the hydrophilic match in biomolecular complexes.

TL;DR: It is demonstrated that the application of the MHP-based techniques in combination with other molecular modeling tools permits significant improvement to the standard computational approaches, provides additional important insights into the intimate molecular mechanisms driving protein assembling in water and in biological membranes, and helps in the computer-aided drug discovery process.

TL;DR: This work used one-week long physical activity records from a 2003–2006 National Health and Nutrition Examination Survey to compare three increasingly accurate biological age models and introduced a novel way to train parametric proportional hazards models suitable for out-of-the-box implementation with any modern machine learning software.

TL;DR: In this paper, the authors investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory and concluded that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

TL;DR: The distance traveled along the aging trajectory was characterized as a natural measure of biological age and demonstrated its significant association with frailty and hazardous lifestyles, along with the remaining lifespan and healthspan of an individual.