Anton O. Chugunov

TL;DR: The PLATINUM web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures and provides a number of tools for quantitative characterization of the hydrophilic match in biomolecular complexes.

TL;DR: It is demonstrated that the application of the MHP-based techniques in combination with other molecular modeling tools permits significant improvement to the standard computational approaches, provides additional important insights into the intimate molecular mechanisms driving protein assembling in water and in biological membranes, and helps in the computer-aided drug discovery process.

TL;DR: It is postulate that IRR is an alkali sensor that functions in the kidney to manage metabolic bicarbonate excess and demonstrates positive cooperativity.

TL;DR: Going beyond a single dimer conformation, the PREDDIMER web tool predicts an ensemble of possible conformations, which may be useful for explanation of a functioning of bitopic membrane proteins, e.g. receptor tyrosine kinases.

TL;DR: It is hypothesize that many lantibiotics exploit the conserved features of lipid-II along with characteristic modulation of the bacterial membrane as the “landing site”, which opens new opportunities for studies on lantIBiotics action and design of novel armament against resistant bacterial strains.