N
Nilabh Shastri
Researcher at University of California, Berkeley
Publications - 38
Citations - 7696
Nilabh Shastri is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Major histocompatibility complex & Antigen. The author has an hindex of 24, co-authored 32 publications receiving 7408 citations. Previous affiliations of Nilabh Shastri include University of California, Los Angeles.
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Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.
TL;DR: The expression cloning of two murine ligands for the lectin-like receptor NKG2D are reported, which are distant relatives of major histocompatibility complex class I molecules and are newly identified potent stimulators of innate immunity.
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The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
TL;DR: The genes encoding the alpha and beta chain of the T-cell receptor and the gamma gene have been cloned, and their structure, organization, ontogeny of expression, pattern of rearrangement, and diversification are now generally understood.
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ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
TL;DR: ERAAP is the missing link between the products of cytosolic processing and the final peptides presented by MHC class I molecules on the cell surface, and its expression is strongly upregulated by interferon-γ.
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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
F. Susan Wong,Jaana T. Karttunen,Caroline Dumont,Li Wen,Irene Visintin,Ingrid M. Pilip,Nilabh Shastri,Eric G. Pamer,Charles A. Janeway +8 more
TL;DR: This is the first identification, to the authors' knowledge, of a CD8 T-cell epitope in an autoimmune disease, and the peptide recognized by the cells is in the same region of the insulin B chain as the epitope recognized by previously isolated pathogenic CD4 T cells.
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Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages
TL;DR: Brefeldin et al. as mentioned in this paper provided morphological evidence that proteins taken up by macropinocytosis can gain access to the cytosol and therefore into the conventional class I MHC pathway.