L
Li Wen
Researcher at Yale University
Publications - 212
Citations - 11346
Li Wen is an academic researcher from Yale University. The author has contributed to research in topics: NOD mice & T cell. The author has an hindex of 51, co-authored 201 publications receiving 9857 citations. Previous affiliations of Li Wen include National Institute for Health Research & Central South University.
Papers
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Journal ArticleDOI
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen,Ruth E. Ley,Ruth E. Ley,Pavel Volchkov,Peter B. Stranges,Lia Avanesyan,Austin C. Stonebraker,Changyun Hu,F. Susan Wong,Gregory L. Szot,Jeffrey A. Bluestone,Jeffrey I. Gordon,Alexander V. Chervonsky +12 more
TL;DR: It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients.
Journal Article
Role of Fas in Autoimmune Diabetes
Conchi Mora,Li Wen,Ramon Gomis,E. Allison Green,Alexander V. Chervonsky,F. Susan Wong,Ainhoa Garcia,Ricahard A. Flavell +7 more
Journal ArticleDOI
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
F. Susan Wong,Jaana T. Karttunen,Caroline Dumont,Li Wen,Irene Visintin,Ingrid M. Pilip,Nilabh Shastri,Eric G. Pamer,Charles A. Janeway +8 more
TL;DR: This is the first identification, to the authors' knowledge, of a CD8 T-cell epitope in an autoimmune disease, and the peptide recognized by the cells is in the same region of the insulin B chain as the epitope recognized by previously isolated pathogenic CD4 T cells.
Journal ArticleDOI
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
Changyun Hu,Daniel Rodriguez-Pinto,Wei Du,Anupama Ahuja,Octavian Henegariu,F. Susan Wong,Mark J. Shlomchik,Li Wen +7 more
TL;DR: It is demonstrated that B cell depletion in mice can prevent or delay diabetes, reverse diabetes after frank hyperglycemia, and lead to the development of cells that suppress disease.
Journal ArticleDOI
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
TL;DR: CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young NOD mice by growing them on B6- RIP-B7-1 islets, and diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.