N
Nilesh R. Ghugre
Researcher at Sunnybrook Health Sciences Centre
Publications - 75
Citations - 3126
Nilesh R. Ghugre is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Myocardial infarction & Medicine. The author has an hindex of 21, co-authored 68 publications receiving 2666 citations. Previous affiliations of Nilesh R. Ghugre include University of Toronto & California Institute of Technology.
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Journal ArticleDOI
MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
John C. Wood,John C. Wood,Cathleen Enriquez,Cathleen Enriquez,Nilesh R. Ghugre,Nilesh R. Ghugre,J. Michael Tyzka,J. Michael Tyzka,Susan Carson,Susan Carson,Marvin D. Nelson,Marvin D. Nelson,Thomas D. Coates,Thomas D. Coates +13 more
TL;DR: Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques, despite significant differences in technique and instrumentation.
Journal ArticleDOI
Practical medical applications of quantitative MR relaxometry
TL;DR: An overview of some promising clinical applications of quantitative relaxometry is provided, followed by a description of the methods and challenges of acquiring accurate and precise quantitative MR maps, and three case studies of quantitative relaxation applied to studying multiple sclerosis, liver iron, and acute myocardial infarction.
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Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.
Rocco Romagnuolo,Hassan Masoudpour,Andreu Porta-Sánchez,Beiping Qiang,Jennifer Barry,Andrew R. Laskary,Xiuling Qi,Stéphane Massé,Karl Magtibay,Hiroyuki Kawajiri,Jun Wu,Tamilla Sadikov,Janet Rothberg,Krishna M. Panchalingam,Emily Titus,Ren-Ke Li,Ren-Ke Li,Peter W. Zandstra,Graham A. Wright,Graham A. Wright,Kumaraswamy Nanthakumar,Kumaraswamy Nanthakumar,Nilesh R. Ghugre,Nilesh R. Ghugre,Gordon Keller,Gordon Keller,Michael A. Laflamme,Michael A. Laflamme +27 more
TL;DR: These findings demonstrate the suitability of the pig model for the preclinical development of a hESC-based cardiac therapy and provide new insights into the mechanistic basis of electrical instability following h ESC-CM transplantation.
Journal ArticleDOI
Improved R2* measurements in myocardial iron overload
Nilesh R. Ghugre,Cathleen Enriquez,Thomas D. Coates,Marvin D. Nelson,John C. Wood,John C. Wood +5 more
TL;DR: To optimize R2*(1/T2*) measurements for cardiac iron detection in sickle cell and thalassemia patients, data is derived from clinical trials and animal studies.
Journal ArticleDOI
Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart.
Angus Z. Lau,Albert P. Chen,Nilesh R. Ghugre,Venkat Ramanan,Wilfred W. Lam,Kim A. Connelly,Graham A. Wright,Charles H. Cunningham +7 more
TL;DR: This article describes the development of a rapid multislice cardiac‐gated spiral 13C imaging pulse sequence consisting of a large flip‐angle spectral‐spatial excitation RF pulse combined with a single‐shot spiral k‐space trajectory for rapid imaging of cardiac metabolism.