N
Nils Wiedemann
Researcher at University of Freiburg
Publications - 91
Citations - 9969
Nils Wiedemann is an academic researcher from University of Freiburg. The author has contributed to research in topics: Translocase of the inner membrane & Translocase of the outer membrane. The author has an hindex of 54, co-authored 86 publications receiving 8715 citations.
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Journal ArticleDOI
Mitochondrial Machineries for Protein Import and Assembly.
Nils Wiedemann,Nikolaus Pfanner +1 more
TL;DR: The versatility and dynamic organization of the mitochondrial protein import machineries are discussed, which are crucial for understanding the integration of protein translocases into a large network that controls organelle biogenesis, function, and dynamics.
Journal ArticleDOI
Mitochondrial proteins: from biogenesis to functional networks
TL;DR: How the mitochondrial protein import machinery functions as a key organizer of these protein networks, its involvement in the formation of membrane contact sites, and how defects in protein import can lead to disease are discussed.
Journal ArticleDOI
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.
Agnieszka Chacinska,Sylvia Pfannschmidt,Nils Wiedemann,Vera Kozjak,Luiza K. Sanjuán Szklarz,Agnes Schulze-Specking,Kaye N. Truscott,Bernard Guiard,Chris Meisinger,Nikolaus Pfanner +9 more
TL;DR: The binding of small Tim proteins to Mia40 is crucial for their transport across the outer membrane and represents an initial step in their assembly into IMS complexes.
Journal ArticleDOI
Machinery for protein sorting and assembly in the mitochondrial outer membrane
Nils Wiedemann,Vera Kozjak,Agnieszka Chacinska,Birgit Schönfisch,Sabine Rospert,Michael T. Ryan,Michael T. Ryan,Nikolaus Pfanner,Chris Meisinger +8 more
TL;DR: The results suggest that the TOM complex, which can transport all kinds of mitochondrial precursor proteins, is not sufficient for the correct integration of outer membrane proteins with a complicated topology, and instead transfers precursor proteins to the SAM complex.
Journal ArticleDOI
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane.
Vera Kozjak,Nils Wiedemann,Dusanka Milenkovic,Christiane Lohaus,Helmut E. Meyer,Bernard Guiard,Chris Meisinger,Nikolaus Pfanner +7 more
TL;DR: The authors have identified Sam50, the second essential protein of the mitochondrial outer membrane, which contains a β-barrel domain conserved from bacteria to man and is a subunit of the SAM complex.