Nimmy Varghese

TL;DR: Investigation of the acute autonomic, subjective, and endocrine effects of single doses of LSD, MDMA, and d-amphetamine in 28 healthy subjects indicates clearly distinct acute effects and may assist the dose-finding in substance-assisted psychotherapy research.

TL;DR: The LSD dose–response curve showed a ceiling effect for subjective good effects, and ego dissolution and anxiety increased further at a dose above 100 µg, which may assist with dose finding for future LSD research.

TL;DR: The finding that LSD acutely increases BDNF levels warrants studies in patient populations, based on preclinical evidence for psychedelic-induced neuroplasticity in humans.

TL;DR: In this paper , a double-blind, randomized, placebo-controlled, crossover design was used in 28 healthy subjects (14 women, 14 men) who underwent five 25-hour sessions and received placebo, LSD (100 and 200 µg), and psilocybin (15 and 30 mg).

TL;DR: The Mediterranean or Okinawan diet could represent a feasible nutritional approach to reduce the risk of developing age-related cognitive impairment and corresponding disorders via the stimulation of mitophagy and thereby ensure a balanced redox state of brain cells.