N
Nobuhiko Miwa
Researcher at Prefectural University of Hiroshima
Publications - 134
Citations - 2984
Nobuhiko Miwa is an academic researcher from Prefectural University of Hiroshima. The author has contributed to research in topics: Ascorbic acid & Oxidative stress. The author has an hindex of 28, co-authored 130 publications receiving 2629 citations.
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Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress.
TL;DR: Artificial slowdown of age-dependent telomere shortening is succeeded by addition of the oxidation-resistant type of ascorbic acid, Asc-2-O-phosphate (Asc2P), which concurrently achieved both extension of cellular life-span and prevention of cell size enlargement indicative of cellular senescence.
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Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis.
TL;DR: Fullerenes did not cause genetic damage in Salmonella typhimurium TA100, TA1535, TA98 and TA1537 and Escherichia coli WP2uvrA/pKM101 and were not of high toxicological significance.
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Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes.
TL;DR: In this paper, PEG-modified fullerene, hydroxy-fullerene and isostearate-mixed fullerenes were shown to scavenge reactive oxygen species (ROS) in the nuclei of UVB-irradiated human skin HaCaT.
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ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?
TL;DR: The role of ACE2 in the pathogenesis of severe and critical conditions of COVID-19 is explained and auspicious strategies for controlling the disease are discussed.
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The water-soluble fullerene derivative "Radical Sponge" exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes.
TL;DR: Cytoprotection by Radical Sponge against UVA was achieved at the advisable range doses of 10-40 microM in contrast to no effect of polyvinylpyrrolidone alone; its dose- dependency was advantageous over that of VC-IP, a tetra-alkyl-esterized provitamin C, which became less cytoprotective above 20 microM.