N
Nobuo Machida
Researcher at Mitsubishi
Publications - 6
Citations - 631
Nobuo Machida is an academic researcher from Mitsubishi. The author has contributed to research in topics: Alzheimer's disease & Tau protein. The author has an hindex of 5, co-authored 6 publications receiving 607 citations.
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Journal ArticleDOI
Tau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease
Hiroyuki Arai,Masanori Terajima,Masakazu Miura,Susumu Higuchi,Taro Muramatsu,Nobuo Machida,Hisatomo Seiki,Sadao Takase,Christopher M. Clark,Virginia M.-Y. Lee,John Q. Trojanowski,Hidetada Sasaki +11 more
TL;DR: The results suggest that cerebrospinal fluid tau might reflect the progressive accumulation of altered tau due to the progressive death of neurons in the AD brain, and that the enzyme‐linked immunosorbent assay of cerebro Spinal Fluid tau may prove to be a reliable and early diagnostic test for AD.
Journal ArticleDOI
Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology.
Hiroyuki Arai,Yu Ichi Morikawa,Makoto Higuchi,Toshifumi Matsui,Christopher M. Clark,Masakazu Miura,Nobuo Machida,Virginia M.-Y. Lee,John Q. Trojanowski,Hidetada Sasaki +9 more
TL;DR: This study suggests that tau may accumulate in the CSF of patients with certain neurodegenerative diseases other than AD and that measurement of CSF-tau may not distinguish AD from DLB.
Journal ArticleDOI
Postoperative delirium and melatonin levels in elderly patients.
Hidetaka Shigeta,Akihiro Yasui,Yuji Nimura,Nobuo Machida,Moto-o Kageyama,Masakazu Miura,Masafumi Menjo,Kyoji Ikeda +7 more
TL;DR: Abnormal melatonin secretion may be involved in postoperative sleep disturbances, which triggered delirium in elderly patients, and in 5 patients with complications, melatonin levels were markedly increased.
Journal ArticleDOI
Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Alzheimer's disease.
Hiroyuki Arai,Masanori Terajima,Masakazu Miura,Susumu Higuchi,Taro Muramatsu,Sachio Matsushita,Nobuo Machida,Takuma Nakagawa,Virginia M.-Y. Lee,John Q. Trojanowski,Hidetada Sasaki +10 more
TL;DR: This study was undertaken to gain insights into the clinical utility of measuring cerebrospinal fluid tau protein to aid in the diagnosis of Alzheimer's disease.
Journal ArticleDOI
Distribution of parvalbumin in specific fibre types of chicken skeletal muscles
TL;DR: Parvalbumin content was high and variable in both PLD and SA, and was undetectable in the ALD, which appears to contain exclusively slow-tonic (ST) fibres, being verified by its myoglobin-rich nature and lowest LDH activity or predominant H-type isozyme characteristics.