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Noor Alnabelseya
Researcher at University of Toronto
Publications - 9
Citations - 381
Noor Alnabelseya is an academic researcher from University of Toronto. The author has contributed to research in topics: Biofilm & Pseudomonas aeruginosa. The author has an hindex of 6, co-authored 8 publications receiving 240 citations. Previous affiliations of Noor Alnabelseya include University of Ottawa & McGill University.
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Journal ArticleDOI
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
Perrin Baker,Preston J. Hill,Brendan D. Snarr,Brendan D. Snarr,Noor Alnabelseya,Matthew J. Pestrak,Mark J. Lee,Mark J. Lee,Laura K. Jennings,John Tam,Roman A. Melnyk,Matthew R. Parsek,Donald C. Sheppard,Donald C. Sheppard,Daniel J. Wozniak,P. Lynne Howell +15 more
TL;DR: These noncytotoxic enzymes potentiated antibiotics because the addition of either enzyme to a sublethal concentration of colistin reduced viable bacterial counts by 2.5 orders of magnitude when used either prophylactically or on established 24-hour biofilms.
Journal ArticleDOI
PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa
Kelly M. Colvin,Noor Alnabelseya,Perrin Baker,John C. Whitney,P. Lynne Howell,Matthew R. Parsek +5 more
TL;DR: The deacetylase activity of PelA is important for the production of the Pel polysaccharide, and results suggest that these mutants were deficient in Pel-dependent biofilm formation and wrinkly colony morphology in vivo.
Posted ContentDOI
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
Perrin Baker,Preston J. Hill,Brendan D. Snarr,Noor Alnabelseya,Matthew J. Pestrak,Mark J. Lee,Laura K. Jennings,John Tam,Roman A. Melnyk,Matthew R. Parsek,Donald C. Sheppard,Daniel J. Wozniak,P. Lynne Howell +12 more
TL;DR: It is demonstrated that these glycoside hydrolases selectively target and degrade the exopolysaccharide component of the biofilm matrix and that nanomolar concentrations of these enzymes can both prevent biofilm formation as well as rapidly disrupt preexisting biofilms in vitro.
Journal ArticleDOI
Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases
François Le Mauff,Natalie C. Bamford,Noor Alnabelseya,Yongzhen Zhang,Perrin Baker,Howard Robinson,Jeroen D. C. Codée,P. Lynne Howell,Donald C. Sheppard +8 more
TL;DR: Insight into PelAh's structure and function necessitate the creation of a new glycoside hydrolase family, GH166, whose structural and mechanistic features, along with those of GH135 (Sph3), are reported here.
Journal ArticleDOI
The phylogeography of Myotis bat-associated rabies viruses across Canada
TL;DR: It is demonstrated that rabies virus has emerged in the Myotis genus independently on multiple occasions and highlights the potential for emergence of new viral-host associations within this genus.