L
Laura K. Jennings
Researcher at University of Washington
Publications - 21
Citations - 1434
Laura K. Jennings is an academic researcher from University of Washington. The author has contributed to research in topics: Pseudomonas aeruginosa & Biofilm. The author has an hindex of 12, co-authored 17 publications receiving 963 citations. Previous affiliations of Laura K. Jennings include Montana State University & University of Montana.
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Journal ArticleDOI
Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix
Laura K. Jennings,Kelly M. Storek,Hannah E. Ledvina,Charlène Coulon,Lindsey S. Marmont,Irina Sadovskaya,Patrick R. Secor,Boo Shan Tseng,Michele Scian,Alain Filloux,Daniel J. Wozniak,P. Lynne Howell,Matthew R. Parsek +12 more
TL;DR: A tool for the direct visualization of Pel in biofilms is developed by combining Pel-specific Wisteria floribunda lectin staining with confocal microscopy and the results indicate that Pel cross-links eDNA in the biofilm stalk via ionic interactions.
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Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
Perrin Baker,Preston J. Hill,Brendan D. Snarr,Brendan D. Snarr,Noor Alnabelseya,Matthew J. Pestrak,Mark J. Lee,Mark J. Lee,Laura K. Jennings,John Tam,Roman A. Melnyk,Matthew R. Parsek,Donald C. Sheppard,Donald C. Sheppard,Daniel J. Wozniak,P. Lynne Howell +15 more
TL;DR: These noncytotoxic enzymes potentiated antibiotics because the addition of either enzyme to a sublethal concentration of colistin reduced viable bacterial counts by 2.5 orders of magnitude when used either prophylactically or on established 24-hour biofilms.
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ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.
Christopher J. Jones,Christopher J. Jones,David E. Newsom,Benjamin J. Kelly,Yasuhiko Irie,Laura K. Jennings,Binjie Xu,Dominique H. Limoli,Joe J. Harrison,Matthew R. Parsek,Peter T White,Daniel J. Wozniak,Daniel J. Wozniak +12 more
TL;DR: The comprehensive regulon of a bifunctional transcriptional regulator is defined and a c-di-GMP mediated mechanism for AmrZ regulation of biofilm formation and chronicity is identified.
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Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis.
Elizabeth B. Burgener,Johanna M. Sweere,Michelle S. Bach,Patrick R. Secor,Naomi L. Haddock,Laura K. Jennings,Rasmus L. Marvig,Helle Krogh Johansen,Elio Rossi,Xiou Cao,Lu Tian,Laurence Nedelec,Søren Molin,Paul L. Bollyky,Carlos Milla +14 more
TL;DR: In vitro analysis showed that Pf phage sequesters these same antibiotics, suggesting that this mechanism may thereby contribute to the selection of antibiotic resistance over time and provide evidence that Pfphage may contribute to clinical outcomes in P. aeruginosa infection in CF.
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Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa
TL;DR: It is found that entropic forces generated by polymers abundant at chronic infection sites can cause bacteria to aggregate by a mechanism known as “depletion aggregation,” which does not require biofilm formation functions, and causes bacteria to become much less susceptible to killing by antibiotics.