I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities of cortical anatomy in AD can be reliably measured across different subject samples, how closely they track symptoms, and whether they are detectable prior to symptoms. An exploratory map of cortical thinning in mild AD was used to define regions of interest that were applied in a hypothesis-driven fashion to other subject samples. Results demonstrate a reliably quantifiable in vivo signature of abnormal cortical anatomy in AD, which parallels known regional vulnerability to AD neuropathology. Thinning in vulnerable cortical regions relates to symptom severity even in the earliest stages of clinical symptoms. Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging. The reliability and clinical validity of AD-related cortical thinning suggests potential utility as an imaging biomarker. This “disease signature” approach to cortical morphometry, in which disease effects are mapped across the cortical mantle and then used to define ROIs for hypothesis-driven analyses, may provide a powerful methodological framework for studies of neuropsychiatric diseases.

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

https://www4.comp.polyu.edu.hk/~cslzhang/paper/FKP_PR_10.pdf

Online finger-knuckle-print verification for personal authentication

Roles of flavonoids against coronavirus infection.

Increasing concerns about environmental issues and depletion of fossil resources lead to a global need for producing more clean energy from renewable sources. For coastal areas or some remote islands, marine tidal current energy is a promising renewable power source due to its high predictability. During the last decades, prototypes of various horizontal and vertical axis marine current turbines (MCT) have been developed around the world. Although reviews on MCTs can be found in some state-of-the-art research papers in the last few years, many of the reported MCT projects were only at the planning/design stage when the papers were written. In fact, some projects do not have any further developments during the several years after their first reporting; and others have already upgraded their original designs and adopted up-scaled versions. In this paper, up-to-date information on large tidal turbine projects over 500 kW is focused. The newest achievements of these large tidal current turbine technologies with their developing histories are presented. These technologies represent the industrial solutions for several pre-commercial MCT farm projects in the coming years. New developments in floating MCT technologies are also included. This paper provides a useful background for researchers in the tidal current energy domain and allows them to know the newest developments in large MCT projects around world.

Developments in large marine current turbine technologies – A review

Sustainable development is a concept mooted to ensure that the needs of the present are met without compromising the needs of the future. Islam has outlined a number of concepts for ensuring that the environment is managed in a responsible and sustainable manner. These concepts are wisdom (hikmah), justice (‘adl), public interest (maslahah) and innovation (ijtihad). The framework of higher purposes of Islamic Divine law or maqasid al-shariah also provides guidance by highlighting five objectives (viz. faith, life, intellect, progeny and property) that need to be protected in carrying out development. However, the challenge lies in putting these concepts and approaches into practice. While there is a good theoretical understanding of these Islamic concepts and approaches, the reality is that many still do not practice what they know in their individual daily lives as well as in policy formulation. Environmental issues including green energy production should not be dismissed simply as a worldly affair. As such, it is imperative for Muslims to not only be aware of these issues, but also to put sustainability into practice in order to achieve the “good life” concept or hayattayibbah.

/pdf/green-energy-towards-sustainability-from-the-islamic-ij1wmsve23.pdf

Green Energy towards Sustainability from the Islamic Perspective

Preservation of progeny or lineage is one of the elements of maqasid al-sharī‘ah (higher objectives of Islamic law). Islam is very particular in matters pertaining to the health of newborns. Consequently, issues concerning female fertility and newborn defects caused by genetic diseases are discussed by Muslim scholars. These two health issues are caused by various factors including defects in reproductive organs and genetic problems inherited from the maternal or paternal side or even caused by mutations such as defective mitochondrial DNA (mtDNA). Assisted reproductive technology (ART) is a medical treatment developed to overcome fertility problems. Recently, this field developed an ART-based defective mitochondrial treatment therapy known as tri-parent baby technology (TPBT). The technology currently being studied involves two types of in vitro fertilisation (IVF) technique: pronuclear transfer (PNT) and maternal spindle transfer (MST). This TPBT could be of great benefit to mankind, including Muslims. However, for Muslims, this technology raises various issues including questions of ethics, morality and parental status. This article presents a brief background of the TPBT as well as challenges for Muslims arising from it. Initial feedback from an Islamic jurisprudential viewpoint is provided by highlighting and analysing scientists’ and current Islamic scholars’ research and insights on this issue.

Advances in Tri-parent Baby Technology: The Bioethical Challenge for Muslims

Fatwa has the most important role to play in the development of society from time to time, and without exception Indonesia as a nation with the largest Muslim majority which requires the role of fatwa surely in order to dealt with or adapt to new issues. For instance, the recent fatwa issued by the Ulama Consultative Assembly (MPU) of Aceh on the prohibition of PUBG caused by an incident of terrorist attacks to the Muslim community in New Zealand. Therefore, the aims of this study is to analyse the fatwa issued by Ulama Consultative Assembly (MPU) of Aceg regarding the status haram of the PUBG based on the findins of Islamic principles, maslahah dan mafsadah. Particularly, the objectives of this research are as follows: 1). To explain the factors behind the Ulama Consultative Assembly (MPU) of Aceh in issuing a forbidden fatwa for the PUBG. 2). To describe the arguments or judgments that became the foundation of Ulama Consultative Assembly (MPU) of Aceh regarding their fatwa. 3). To analyse the haram fatwa against PUBG issued by Ulama Consultative Assembly (MPU) of Aceh through the concept of masalah and mafsadah.

/pdf/analysis-on-fatwa-of-majelis-permusyawaratan-ulama-aceh-mpu-11z6k0cjg9.pdf

Analysis on fatwa of majelis permusyawaratan ulama aceh (mpu) on against prohibition of pubg: a legal view based on maslahah and mafsadah

An insight in Salmonella typhi associated autoimmunity candidates' prediction by molecular mimicry

Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern. Multiple drug resistance has also emerged in several cancer cell types, leaving them unresponsive to the many cancer treatments. Such a condition always prompts the development of next-generation cancer therapies that have a better chance of inhibiting selective target macromolecules with less toxicity. Therefore, in the present study, extensive computational approaches were implemented combining molecular docking and dynamic simulation studies for identifying potent pyrazole-based inhibitors or modulators for CRMP2, C-RAF, CYP17, c-KIT, VEGFR, and HDAC proteins. All of these proteins are in some way linked to the development of numerous forms of cancer, including breast, liver, prostate, kidney, and stomach cancers. In order to identify potential compounds, 63 in-house synthesized pyrazole-derivative compounds were docked with each selected protein. In addition, single or multiple standard drug compounds of each protein were also considered for docking analyses and their results used for comparison purposes. Afterward, based on the binding affinity and interaction profile of pyrazole compounds of each protein, potentially strong compounds were filtered out and further subjected to 1000 ns MD simulation analyses. Analyzing parameters such as RMSD, RMSF, RoG and protein–ligand contact maps were derived from trajectories of simulated protein–ligand complexes. All these parameters turned out to be satisfactory and within the acceptable range to support the structural integrity and interaction stability of the protein–ligand complexes in dynamic state. Comprehensive computational analyses suggested that a few identified pyrazole compounds, such as M33, M36, M72, and M76, could be potential inhibitors or modulators for HDAC, C-RAF, CYP72 and VEGFR proteins, respectively. Another pyrazole compound, M74, turned out to be a very promising dual inhibitor/modulator for CRMP2 and c-KIT proteins. However, more extensive study may be required for further optimization of the selected chemical framework of pyrazole derivatives to yield improved inhibitory activity against each studied protein receptor.

/pdf/in-silico-identification-of-promising-new-pyrazole-irzoffpj.pdf

In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics

Noor Naemah Abdul Rahman

Papers

Green Energy towards Sustainability from the Islamic Perspective

Advances in Tri-parent Baby Technology: The Bioethical Challenge for Muslims

Analysis on fatwa of majelis permusyawaratan ulama aceh (mpu) on against prohibition of pubg: a legal view based on maslahah and mafsadah

An insight in Salmonella typhi associated autoimmunity candidates' prediction by molecular mimicry

In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics