C
Christopher E. Rudd
Researcher at Université de Montréal
Publications - 194
Citations - 13790
Christopher E. Rudd is an academic researcher from Université de Montréal. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 61, co-authored 178 publications receiving 12771 citations. Previous affiliations of Christopher E. Rudd include Hôpital Maisonneuve-Rosemont & Imperial College London.
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Journal ArticleDOI
CD28 and CTLA-4 coreceptor expression and signal transduction.
TL;DR: The current knowledge of the CD28 and CTLA‐4 signaling mechanisms [involving phosphatidylinositol 3 kinase (PI3K), growth factor receptor‐bound protein 2 (Grb2), Filamin A, protein kinase C θ (PKCθ), and phosphatases] that control T‐cell immunity are outlined.
Journal ArticleDOI
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes
TL;DR: In this paper, the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (PTK) of 55-60 kDa, which is expressed specifically in T cells.
Journal ArticleDOI
Reversal of the TCR stop signal by CTLA-4.
Helga Schneider,Helga Schneider,Jos Downey,Andrew M. Smith,Bernd H. Zinselmeyer,Bernd H. Zinselmeyer,Catherine M. Rush,Catherine M. Rush,James M. Brewer,James M. Brewer,Bin Wei,Nancy Hogg,Paul Garside,Paul Garside,Christopher E. Rudd,Christopher E. Rudd +15 more
TL;DR: It is shown that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)–induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells, which suggests a fundamentally different model of reverse stop signaling.
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The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
Anthony J. Coyle,Sophie M. Lehar,Clare M. Lloyd,Jane Tian,Tracy Delaney,Stephen Manning,Trang Nguyen,Tim Burwell,Helga Schneider,Jose Angel Gonzalo,Michael Gosselin,Laura Rudolph Owen,Christopher E. Rudd,Jose-Carlos Gutierrez-Ramos +13 more
TL;DR: It is suggested that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo.
Journal ArticleDOI
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Yu-Hwa Huang,Chen Zhu,Yasuyuki Kondo,Ana C. Anderson,Amit Gandhi,Andrew Russell,Stephanie K. Dougan,Britt-Sabina Petersen,Espen Melum,Thomas Pertel,Kiera L. Clayton,Monika Raab,Qiang Chen,Nicole Beauchemin,Paul J. Yazaki,Michal Pyzik,Mario A. Ostrowski,Jonathan N. Glickman,Christopher E. Rudd,Hidde L. Ploegh,Andre Franke,Gregory A. Petsko,Vijay K. Kuchroo,Richard S. Blumberg +23 more
TL;DR: In this article, the authors showed that CEACAM1 facilitates the maturation and cell surface expression of TIM-3 by forming a heterodimeric interaction in cis through the highly related membrane-distal N-terminal domains of each molecule.