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Norbert Claude Gorin
Researcher at Pierre-and-Marie-Curie University
Publications - 46
Citations - 3078
Norbert Claude Gorin is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Transplantation & Acute leukemia. The author has an hindex of 23, co-authored 45 publications receiving 2816 citations. Previous affiliations of Norbert Claude Gorin include French Institute of Health and Medical Research.
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Mesenchymal stem cells home to injured tissues when co‐infused with hematopoietic cells to treat a radiation‐induced multi‐organ failure syndrome
Alain Chapel,Jean Marc Bertho,Morad Bensidhoum,Loic Fouillard,Randell G. Young,Johanna Frick,Christelle Demarquay,Frédérique Cuvelier,Emilie Mathieu,François Trompier,N. Dudoignon,Claire Germain,Christelle Mazurier,Jocelyne Aigueperse,Jade Borneman,Norbert Claude Gorin,Patrick Gourmelon,Dominique Thierry +17 more
TL;DR: The potential of a combined infusion of autologous ex vivo expanded hematopoietic cells with mesenchymal (MSCs) for the treatment of multi‐organ failure syndrome following irradiation in a non‐human primate model is investigated.
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Donor Lymphocyte Infusion in the Treatment of First Hematological Relapse After Allogeneic Stem-Cell Transplantation in Adults With Acute Myeloid Leukemia: A Retrospective Risk Factors Analysis and Comparison With Other Strategies by the EBMT Acute Leukemia Working Party
Christoph Schmid,Myriam Labopin,Arnon Nagler,Martin Bornhäuser,Jürgen Finke,Athanasios Fassas,Liisa Volin,Gunham Gurman,Johan Maertens,Pierre Bordigoni,Ernst Holler,Gerhard Ehninger,Emmanuelle Polge,Norbert Claude Gorin,Hans-Jochem Kolb,Vanderson Rocha +15 more
TL;DR: The results confirm that the clinical benefit of donor lymphocyte infusion in the treatment of relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation (HSCT) is limited to a minority of patients.
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Homing of in vitro expanded Stro-1 or Stro-1 human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment
Morad Bensidhoum,Alain Chapel,Sabine François,Christelle Demarquay,Christelle Mazurier,Loic Fouillard,Sandrine Bouchet,Jean Marc Bertho,Patrick Gourmelon,Jocelyne Aigueperse,Pierre Charbord,Norbert Claude Gorin,Dominique Thierry,Manuel Rodríguez López +13 more
TL;DR: The data show that cotransplantation of expanded Stro-1(-) cells with CD34(+) cells resulted in a significant increase of human CD45, CD34, CD19, and CD11b cells detected in blood or in bone marrow (BM) and spleen as compared with the infusion of CD34 (+) cells alone.
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Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia.
Norbert Schmitz,Meral Beksac,Dirk Hasenclever,Andrea Bacigalupo,Tapani Ruutu,Arnon Nagler,Eliane Gluckman,Nigel H. Russell,Jane F. Apperley,Norbert Claude Gorin,Jeff Szer,Kenneth F. Bradstock,Agnès Buzyn,Peter U. Clark,Keith M. Borkett,Alois Gratwohl +15 more
TL;DR: Peripheral blood is an equivalent source of hematopoietic stem cells compared with bone marrow if administered to patients with standard-risk leukemias and long-term observation of patients with different diseases and stages of disease is necessary to define the role of both sources of stem cells.
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Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells.
Aisha Nasef,Alain Chapel,Christelle Mazurier,Sandrine Bouchet,Manuel Rodríguez López,Noelle Mathieu,Luc Sensebé,Yizhuo Zhang,Norbert Claude Gorin,Dominique Thierry,L. Fouillard,L. Fouillard +11 more
TL;DR: MSC appear to induce T-cell tolerance by two distinct mechanisms, the first of which does not require cell contact, induces expression of the tolerogenic genes IDO, LIF, and HLA-G, and the second mechanism, which is contact dependent, modulates IL-10 and TGF-beta gene expression.