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Norihiko Sasaki
Researcher at Soka University of America
Publications - 10
Citations - 271
Norihiko Sasaki is an academic researcher from Soka University of America. The author has contributed to research in topics: Cellular differentiation & Sulfation. The author has an hindex of 5, co-authored 10 publications receiving 257 citations.
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Journal ArticleDOI
Heparan Sulfate Regulates Self-renewal and Pluripotency of Embryonic Stem Cells
Norihiko Sasaki,Kazuhiko Okishio,Kumiko Ui-Tei,Kaoru Saigo,Akiko Kinoshita-Toyoda,Hidenao Toyoda,Tomoaki Nishimura,Yasuo Suda,Michiko Hayasaka,Kazunari Hanaoka,Seiji Hitoshi,Kazuhiro Ikenaka,Shoko Nishihara +12 more
TL;DR: RNA interference-mediated knockdown of HS chain elongation inhibited mouse ES cell self-renewal and induced spontaneous differentiation of the cells into extraembryonic endoderm, and autocrine/paracrine Wnt/β-catenin signaling through HS chains was found to be required for the regulation of Nanog expression.
Journal ArticleDOI
Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.
Shin Kamiyama,Norihiko Sasaki,Emi Goda,Kumiko Ui-Tei,Kaoru Saigo,Hisashi Narimatsu,Yoshifumi Jigami,Reiji Kannagi,Tatsuro Irimura,Shoko Nishihara +9 more
TL;DR: Findings indicate that PAPST2 is a PAPS transporter gene involved in the synthesis of sulfated glycoconjugates in the colon, and this gene is predominantly expressed in human colon tissues.
Journal ArticleDOI
The 3′-Phosphoadenosine 5′-Phosphosulfate Transporters, PAPST1 and 2, Contribute to the Maintenance and Differentiation of Mouse Embryonic Stem Cells
Norihiko Sasaki,Takuya Hirano,Tomomi Ichimiya,Masahiro Wakao,Kazumi Hirano,Akiko Kinoshita-Toyoda,Hidenao Toyoda,Yasuo Suda,Shoko Nishihara +8 more
TL;DR: It is proposed that PAPST-dependent sulfation of HS or CS chains, which is regulated developmentally, regulates the extrinsic signaling required for the maintenance and normal differentiation of mESCs.
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Identification of the Drosophila core 1 β1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes
Hideki Yoshida,Takashi J. Fuwa,Mikiko Arima,Hiroshi Hamamoto,Norihiko Sasaki,Tomomi Ichimiya,Ken-ichi Osawa,Ryu Ueda,Shoko Nishihara +8 more
TL;DR: The CG9520 gene Drosophila core 1 beta1,3-galactosyltransferase 1 is named because it is responsible for the synthesis and function of T antigen in vivo.
Journal ArticleDOI
Drosophila β1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids
Norihiko Sasaki,Hideki Yoshida,Takashi J. Fuwa,Akiko Kinoshita-Toyoda,Hidenao Toyoda,Yoshio Hirabayashi,Hideki Ishida,Ryu Ueda,Shoko Nishihara +8 more
TL;DR: Results suggest that dbeta4GalNAcTA acts on the terminal GlcNAc residue of some glycans for the synthesis of LDN, and the LDN structure may play a role in the physiological or neuronal development of Drosophila.