Noritaka Isogai

TL;DR: Living vascular grafts engineered from autologous cells and biodegradable polymers functioned well in the pulmonary circulation as a pulmonary artery replacement and demonstrated an increase in diameter suggesting growth and development of endothelial lining and extracellular matrix, including collagen and elastic fibers.

TL;DR: In this article, the authors describe the formation of small phalanges and whole joints from three types of bovine-cell sources transplanted onto biodegradable polymer matrices.

TL;DR: Bovine chondrocytes obtained from different cartilaginous sites in an animal may elicit distinct responses during their respective development of a tissue-engineered neocartilage, and this observation is critical in the design and elaboration of any tissue- engineered cartilage model.

TL;DR: The collective data suggest that nasoseptal, articular, and auricular cartilages represent harvest sites suitable for development of tissue‐engineered human ear models with retention over time of three‐dimensional construct architecture, gene expression, and extracellular matrix composition comparable to normal, nonmineralizing cartilage.

TL;DR: The feasibility of initiating site-directed formation of bone structures at heterotopic tissue sites by means of injection of cultured periosteal cells and matrix in a fibrin glue carrier is supported.