Hydrogels for tissue engineering: scaffold design variables and applications.

Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally, special attention is given to the microfabrication techniques that are currently resulting in important advances in the field.

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Hydrogels in regenerative medicine

1: Magnetic Particles: Preparation, Properties and Applications: M. Ozaki. 2: Maghemite (gamma-Fe2O3): A Versatile Magnetic Colloidal Material C.J. Serna, M.P. Morales. 3: Dynamics of Adsorption and Oxidation of Organic Molecules on Illuminated Titanium Dioxide Particles Immersed in Water M.A. Blesa, R.J. Candal, S.A. Bilmes. 4: Colloidal Aggregation in Two-Dimensions A. Moncho-Jorda, F. Martinez-Lopez, M.A. Cabrerizo-Vilchez, R. Hidalgo Alvarez, M. Quesada-PMerez. 5: Kinetics of Particle and Protein Adsorption Z. Adamczyk.

Surface and Colloid Science

Advanced functional polymer membranes

Progress in the production and modification of PVDF membranes

Almost 30 years have passed since a term ‘tissue engineering’ was created to represent a new concept that focuses on regeneration of neotissues from cells with the support of biomaterials and growth factors. This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have been also aiming at replacing lost or severely damaged tissues or organs. However, the tissues regenerated by this tissue engineering and widely applied to patients are still very limited, including skin, bone, cartilage, capillary and periodontal tissues. What are the reasons for such slow advances in clinical applications of tissue engineering? This article gives the brief overview on the current tissue engineering, covering the fundamentals and applications. The fundamentals of tissue engineering involve the cell sources, scaffolds for cell expansion and differentiation and carriers for growth factors. Animal and human trials are the major part of the applications. Based on these results, some critical problems to be resolved for the advances of tissue engineering are addressed from the engineering point of view, emphasizing the close collaboration between medical doctors and biomaterials scientists.

https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2006.0124

Challenges in tissue engineering

Polymer surface with graft chains

To the Editor: Various vascular grafts are commonly used in the reconstruction of cardiovascular tissues. However, prosthetic or bioprosthetic materials lack growth potential and therefore in child...

Transplantation of a tissue-engineered pulmonary artery.

Properties and morphology of poly(L-lactide). 4. Effects of structural parameters on long-term hydrolysis of poly(L-lactide) in phosphate-buffered solution

Yoshito Ikada

Papers

Challenges in tissue engineering

Polymer surface with graft chains

Transplantation of a tissue-engineered pulmonary artery.

Properties and morphology of poly(L-lactide). 4. Effects of structural parameters on long-term hydrolysis of poly(L-lactide) in phosphate-buffered solution

Successful application of tissue engineered vascular autografts: clinical experience.