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Noriyuki Habuka
Researcher at Japan Tobacco
Publications - 25
Citations - 2225
Noriyuki Habuka is an academic researcher from Japan Tobacco. The author has contributed to research in topics: Peptide sequence & Ribosome-inactivating protein. The author has an hindex of 15, co-authored 25 publications receiving 2185 citations. Previous affiliations of Noriyuki Habuka include University of Tsukuba & Tokyo Institute of Technology.
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Journal ArticleDOI
Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex
Charles R. Kissinger,Hans E. Parge,Daniel R. Knighton,Cristina Lewis,L. A. K. Pelletier,Anna Tempczyk,Vincent J. Kalish,Kathleen D. Tucker,Richard E. Showalter,Ellen W. Moomaw,Louis N. Gastinel,Noriyuki Habuka,Xinghai Chen,Fausto Maldonado,John E. Barker,Russell J. Bacquet,J. Ernest Villafranca +16 more
TL;DR: The metal-site geometry and active-site water structure suggest a catalytic mechanism involving nucleophilic attack on the substrate phosphate by a metal-activated water molecule.
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The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site
R. A. Love,Hans E. Parge,John A Wickersham,Zdenek Hostomsky,Noriyuki Habuka,Noriyuki Habuka,Ellen W. Moomaw,Tsuyoshi Adachi,Tsuyoshi Adachi,Zuzana Hostomska +9 more
TL;DR: The structure of NS3 proteinase from HCV BK strain was determined by X-ray crystallography at 2.4 angstrom resolution and has a structural zinc-binding site and a long N-terminus that interacts with neighboring molecules by binding to a hydrophobic surface patch.
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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.
Hideo Ago,Tsuyoshi Adachi,Atsuhito Yoshida,Masaki Yamamoto,Noriyuki Habuka,Kimio Yatsunami,Masashi Miyano +6 more
TL;DR: It is proposed that the unique alpha fingers might represent a common structural discriminator of the template-primer duplex that distinguishes between RNA and DNA during the replication of positive single-stranded RNA by viral RdRps.
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Amino acid sequence of Mirabilis antiviral protein, total synthesis of its gene and expression in Escherichia coli.
TL;DR: The complete amino acid sequence of Mirabilis antiviral protein (MAP), which is composed of 250 amino acids having a combined molecular weight of 27,833 and contains 23 lysine residues and 7 arginine residues, is determined.
Journal ArticleDOI
The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase.
Tsuyoshi Adachi,Hideo Ago,Noriyuki Habuka,Kayo Okuda,Masakazu Komatsu,Satoru Ikeda,Kimio Yatsunami +6 more
TL;DR: Structural comparison of the NS5B proteins indicates that the activation was caused by elimination of a unique hydrophobic interaction between the three C-terminal residues and a shallowly concave pocket consisting of thumb and palm domains.