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Noriyuki Shibata
Researcher at Montefiore Medical Center
Publications - 161
Citations - 5332
Noriyuki Shibata is an academic researcher from Montefiore Medical Center. The author has contributed to research in topics: SOD1 & Amyotrophic lateral sclerosis. The author has an hindex of 34, co-authored 150 publications receiving 4861 citations.
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IMMUNOHISTOCHEMICAL DEMONSTRATION OF Cu/Zn SUPEROXIDE DISMUTASE IN THE SPINAL CORD OF PATIENTS WITH FAMILIAL AMYOTRO-PHIC LATERAL SCLEROSIS
Noriyuki Shibata,Asao Hirano,Makio Kobayashi,Kohtaro Asayama,Takahiko Umahara,Takashi Komori,Akito Ikemoto +6 more
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Presence of Cu/Zn superoxide dismutase (SOD) immunoreactivity in neuronal hyaline inclusions in spinal cords from mice carrying a transgene for Gly93Ala mutant human Cu/Zn SOD.
Noriyuki Shibata,Asao Hirano,Makio Kobayashi,M. C. Dal Canto,Mark E. Gurney,Takashi Komori,Takahiko Umahara,Kohtaro Asayama +7 more
TL;DR: The results indicate that Cu/Zn SOD colocalizes with ubiquitin and phosphorylated NFP in NHIs of mice expressing mutant Cu/ Zn S OD; similar findings have been shown for Lewy body-like inclusions of familial ALS patients with Cu/zn Sod mutation.
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Protein-bound 4-hydroxy-2-nonenal: an endogenous triggering antigen of antI-DNA response.
Kazuyo Toyoda,Ritsuko Nagae,Mitsugu Akagawa,Kosuke Ishino,Takahiro Shibata,Sohei Ito,Noriyuki Shibata,Tomoko Yamamoto,Makio Kobayashi,Yoshinari Takasaki,Tsukasa Matsuda,Koji Uchida +11 more
TL;DR: Evidence is provided to suspect an etiologic role for lipid peroxidation in autoimmune diseases and generated monoclonal antibodies, showing recognition specificity toward DNA, and found that they can bind to two structurally distinct antigens.
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Preparation of monoclonal antibodies reactive with beta-1,2-linked oligomannosyl residues in the phosphomannan-protein complex of Candida albicans NIH B-792 strain.
TL;DR: Hybridomas obtained by fusing the spleen cells of BALB/c female mice hyperimmunized with heat-killed yeast-form cells of Candida albicans NIH B-792 strain and a mouse myeloma cell line produced antibodies to beta-1,2-linked oligomannosyl residues in the phosphomannan-protein complex of the parent cells.
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Detection of lipofuscin-like fluorophore in oxidized human low-density lipoprotein: 4-Hydroxy-2-nonenal as a potential source of fluorescent chromophore
Koichi Itakura,Koichi Itakura,Tomoko Oya-Ito,Toshihiko Osawa,Satoshi Yamada,Shinya Toyokuni,Noriyuki Shibata,Makio Kobayashi,Koji Uchida +8 more
TL;DR: Immunohistochemical analysis of atherosclerotic lesions from the human aorta showed that the fluorophore was indeed present in the lesions, and intense positivity was primarily associated with macrophage‐derived foam cells and thickening of the neointima of the arterial walls.