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Noriyuki Shibata
Researcher at Montefiore Medical Center
Publications - 161
Citations - 5332
Noriyuki Shibata is an academic researcher from Montefiore Medical Center. The author has contributed to research in topics: SOD1 & Amyotrophic lateral sclerosis. The author has an hindex of 34, co-authored 150 publications receiving 4861 citations.
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Journal ArticleDOI
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
Toru Furukawa,Yuko Kuboki,Etsuko Tanji,Shoko Yoshida,Takashi Hatori,Masakazu Yamamoto,Noriyuki Shibata,Kyoko Shimizu,Naoyuki Kamatani,Keiko Shiratori +9 more
TL;DR: Results indicate that GNAS mutations are common and specific for IPMN, and activation of G-protein signaling appears to play a pivotal role in IPMN.
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15-Deoxy-Δ12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES
Takahiro Shibata,Mitsuhiro Kondo,Toshihiko Osawa,Noriyuki Shibata,Makio Kobayashi,Koji Uchida +5 more
TL;DR: A novel metabolic pathway is established, in which PGD(2), a major cyclooxygenase product in a variety of tissues, is converted to 15d-PGJ(2) via an albumin-independent mechanism, and is utilized in the cells during inflammation.
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Intense Superoxide Dismutase-1 Immunoreactivity in Intracytoplasmic Hyaline Inclusions of Familial Amyotrophic Lateral Sclerosis with Posterior Column Involvement
Noriyuki Shibata,Asao Hirano,Makio Kobayashi,Teepu Siddique,Han Xiang Deng,Wu Yen Hung,Takeo Kato,Kohtaro Asayama +7 more
TL;DR: The results suggest that SOD1 is a component of IHIs and may interact with ubiquitin and neurofilament protein, and point to the possibility that the presence of intense S OD1 immunoreactivity in the IHIS may be of relevance in processes involving structurally altered Sod1 molecules encoded by the mutated gene.
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Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries IMPLICATION IN THE ANTI-ATHEROSCLEROTIC MECHANISM OF DIETARY FLAVONOIDS
Yoshichika Kawai,Tomomi Nishikawa,Yuko Shiba,Satomi Saito,Kaeko Murota,Noriyuki Shibata,Makio Kobayashi,Masaya Kanayama,Koji Uchida,Junji Terao +9 more
TL;DR: It is suggested that injured/inflamed arteries with activated macrophages are the potential targets of the metabolites of dietary quercetin in the aorta.
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Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
Noriyuki Shibata,Ryoji Nagai,Koji Uchida,Seikoh Horiuchi,Satoshi Yamada,Asao Hirano,Motoko Kawaguchi,Tomoko Yamamoto,Shoichi Sasaki,Makio Kobayashi +9 more
TL;DR: In sporadic ALS, both lipid peroxidation and protein glycoxidation are enhanced in the spinal cord motor neurons and glial cells, and suggest that the formation of certain products in these abnormal reactions is implicated in motor neuron degeneration.