T
Takahiro Shibata
Researcher at Nagoya University
Publications - 112
Citations - 5040
Takahiro Shibata is an academic researcher from Nagoya University. The author has contributed to research in topics: Chemistry & Epitope. The author has an hindex of 30, co-authored 103 publications receiving 4434 citations. Previous affiliations of Takahiro Shibata include Tohoku University & University of Shizuoka.
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Journal ArticleDOI
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
Akira Kobayashi,Moon Il Kang,Yoriko Watai,Kit I. Tong,Takahiro Shibata,Koji Uchida,Masayuki Yamamoto +6 more
TL;DR: The contention that Nrf2 protein synthesized de novo after exposure to stress accumulates in the nucleus by bypassing the Keap1 gate supports the contention that the sensory mechanism of oxidative and electrophilic stresses is closely linked to the degradation mechanism of NRF2.
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15-Deoxy-Δ12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES
Takahiro Shibata,Mitsuhiro Kondo,Toshihiko Osawa,Noriyuki Shibata,Makio Kobayashi,Koji Uchida +5 more
TL;DR: A novel metabolic pathway is established, in which PGD(2), a major cyclooxygenase product in a variety of tissues, is converted to 15d-PGJ(2) via an albumin-independent mechanism, and is utilized in the cells during inflammation.
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Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2
Ken Itoh,Mie Mochizuki,Yukio Ishii,Tetsuro Ishii,Takahiro Shibata,Yoshiyuki Kawamoto,Vincent P. Kelly,Kiyohisa Sekizawa,Koji Uchida,Masayuki Yamamoto +9 more
TL;DR: It is demonstrated that Nrf2 regulates the inflammation process downstream of 15d-PGJ2 by orchestrating the recruitment of inflammatory cells and regulating the gene expression within those cells.
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Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration
Motohiro Nishida,Tomohiro Sawa,Naoyuki Kitajima,Katsuhiko Ono,Hirofumi Inoue,Hideshi Ihara,Hozumi Motohashi,Masayuki Yamamoto,Makoto Suematsu,Hitoshi Kurose,Albert van der Vliet,Bruce A. Freeman,Takahiro Shibata,Koji Uchida,Yoshito Kumagai,Takaaki Akaike +15 more
TL;DR: It is reported that enzymatically generated hydrogen sulfide anion (HS(-)) regulates the metabolism and signaling actions of various electrophiles and acts as a unique mechanism for regulating electrophile-mediated redox signaling.
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Differential Responses of the Nrf2-Keap1 System to Laminar and Oscillatory Shear Stresses in Endothelial Cells*
Tomonori Hosoya,Atsushi Maruyama,Moon Il Kang,Yukie Kawatani,Takahiro Shibata,Koji Uchida,Ken Itoh,Masayuki Yamamoto +7 more
TL;DR: O-flow inhibits Nrf2 activity at the DNA binding step, thereby suppressing athero-protective gene expression and hence predisposing the blood vessels to the formation of atherosclerosis.