Nouf N. Laqtom

TL;DR: In this article, a method for the rapid isolation of mammalian lysosomes and use it to quantitatively profile lyssomal metabolites under various cell states was described. And the results reveal the dynamic nature of LSA metabolites and that V-ATPase-and mTOR-dependent mechanisms exist for controlling LSA amino acid efflux.

TL;DR: Analysis of the contents of cultured human cells showed that efflux from the lysosome of most essential amino acids (but not that of most other amino acids) is a regulated process, and that V-ATPase- and mTOR-dependent mechanisms exist for controlling lysOSomal amino acid efflux.

TL;DR: It is proposed that NUFIP1 is a receptor for the selective autophagy of ribosomes, and nutrient levels and mTOR dynamically modulate the lysosomal proteome.

TL;DR: Identification of miR-378-3p as an IL-4Rα-induced microRNA led to the discovery that Akt regulates the newly discovered mechanism ofIL-4-driven macrophage proliferation, suggesting that negative regulation of Akt signaling via microRNAs might play a central role in limiting MΦ expansion and alternative activation during type 2 inflammatory settings.

TL;DR: The structure shows why Raptor binds only to a specific nucleotide conformation of the Rag heterodimer and suggests a model for how mTORC1 would dock onto the lysosomal surface, which is a key step in its activation.