N
Nozomi Nakayama-Ratchford
Researcher at Stanford University
Publications - 5
Citations - 2934
Nozomi Nakayama-Ratchford is an academic researcher from Stanford University. The author has contributed to research in topics: Carbon nanotubes in medicine & Prodrug. The author has an hindex of 5, co-authored 5 publications receiving 2809 citations. Previous affiliations of Nozomi Nakayama-Ratchford include Massachusetts Institute of Technology.
Papers
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Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery.
TL;DR: This work introduces the concept of "functionalization partitioning" of SWNTs, i.e., imparting multiple chemical species, such as PEG, drugs, and fluorescent tags, with different functionalities onto the surface of the same nanotube, which should open up new opportunities in chemical, biological, and medical applications of novel nanomaterials.
Journal ArticleDOI
A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice
Meike L. Schipper,Nozomi Nakayama-Ratchford,Corrine R. Davis,Nadine Wong Shi Kam,Pauline Chu,Zhuang Liu,Xiaoming Sun,Hongjie Dai,Sanjiv S. Gambhir +8 more
TL;DR: Histology and Raman microscopic mapping demonstrate that functionalized single-walled carbon nanotubes persisted within liver and spleen macrophages for 4 months without apparent toxicity, and results encourage further confirmation studies with larger groups of animals.
Journal ArticleDOI
Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design
TL;DR: Amine-functionalized soluble single-walled carbon nanotubes were derivatized with cisplatin prodrug conjugates as a delivery system by which to internalize multiple prodrug centers and the entrapment of the SWNTs within the endosomes was confirmed.
Journal ArticleDOI
Noncovalent functionalization of carbon nanotubes by fluorescein-polyethylene glycol: supramolecular conjugates with pH-dependent absorbance and fluorescence.
TL;DR: It is found serendipitously that fluorescein, a widely used fluorophore, can strongly adsorb onto the sidewall of the SWNTs, likely via π-stacking, and the hydrophilic PEG chain imparts high aqueous solubility.
Patent
Soluble Nanoparticles as Delivery Systems for Prodrugs
TL;DR: In this article, the authors described a method to deliver a prodrug in an elevated oxidative state to cells by means of graphitic nanoparticles to which the prodrug is attached by a hydrophilic polymer and which have been made soluble by a PEG.