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Nuria Fonknechten
Researcher at Université Paris-Saclay
Publications - 17
Citations - 3206
Nuria Fonknechten is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Spastin & Hereditary spastic paraplegia. The author has an hindex of 14, co-authored 17 publications receiving 2937 citations. Previous affiliations of Nuria Fonknechten include Centre national de la recherche scientifique & Commissariat à l'énergie atomique et aux énergies alternatives.
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Journal ArticleDOI
Deciphering the evolution and metabolism of an anammox bacterium from a community genome
Marc Strous,Eric Pelletier,Sophie Mangenot,Thomas Rattei,Angelika Lehner,Angelika Lehner,Michael W. Taylor,Matthias Horn,Holger Daims,Delphine Bartol-Mavel,Patrick Wincker,Valérie Barbe,Nuria Fonknechten,David Vallenet,Béatrice Ségurens,Chantal Schenowitz-Truong,Claudine Médigue,Astrid Collingro,Berend Snel,Bas E. Dutilh,Huub J. M. Op den Camp,Chris van der Drift,Irina Cirpus,Katinka T. van de Pas-Schoonen,Harry R. Harhangi,Laura van Niftrik,Laura van Niftrik,Markus Schmid,Jan T. Keltjens,Jack van de Vossenberg,Boran Kartal,Harald Meier,Dmitrij Frishman,Martijn A. Huynen,Hans-Werner Mewes,Jean Weissenbach,Mike S. M. Jetten,Mike S. M. Jetten,Michael Wagner,Denis Le Paslier +39 more
TL;DR: This work uses environmental genomics—the reconstruction of genomic data directly from the environment—to assemble the genome of the uncultured anammox bacterium Kuenenia stuttgartiensis from a complex bioreactor community, and identifies candidate genes responsible for ladderane biosynthesis and biological hydrazine metabolism.
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Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia
Jamilé Hazan,Nuria Fonknechten,Delphine Mavel,Caroline Paternotte,Delphine Samson,François Artiguenave,Claire-Sophie Davoine,Corinne Cruaud,Alexandra Durr,Patrick Wincker,Philippe Brottier,Laurence Cattolico,Valérie Barbe,Jean-Marc Burgunder,Jean-François Prud'homme,Alexis Brice,Bertrand Fontaine,Roland Heilig,Jean Weissenbach +18 more
TL;DR: The sequence homologies and putative subcellular localization of spastin suggest that this ATPase is involved in the assembly or function of nuclear protein complexes.
Journal ArticleDOI
Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium
Valérie Barbe,David Vallenet,Nuria Fonknechten,Annett Kreimeyer,Sophie Oztas,Laurent Labarre,Stéphane Cruveiller,Catherine Robert,Simone Duprat,Patrick Wincker,L. Nicholas Ornston,Jean Weissenbach,Philippe Marlière,Georges N. Cohen,Claudine Médigue +14 more
TL;DR: Genome analysis of the Acinetobacter ADP1 revealed genes for metabolic pathways involved in utilization of a large variety of compounds, supporting the view that the cycle itself is centrally geared to the catabolic capabilities of this exceptionally versatile organism.
Journal ArticleDOI
Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia
Nuria Fonknechten,Delphine Mavel,Paula C. Byrne,Claire-Sophie Davoine,Corinne Cruaud,Dominikus Bönsch,Delphine Samson,Paula Coutinho,Michael Hutchinson,P. McMonagle,Jean-Marc Burgunder,Antonio Tartaglione,Olivier Heinzlef,Imed Feki,Thomas Deufel,Nollaig A. Parfrey,Alexis Brice,Bertrand Fontaine,Jean-François Prud'homme,Jean Weissenbach,Alexandra Durr,Jamilé Hazan +21 more
TL;DR: The clinical analysis of the 238 mutation carriers revealed a high proportion of both asymptomatic carriers and patients unaware of symptoms, and permitted the redefinition of this frequent form of AD-HSP.
Journal ArticleDOI
A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition
Anne Tarrade,Coralie Fassier,Sabrina Courageot,Delphine Charvin,Jeremie Vitte,Leticia Peris,Alain Thorel,Etienne Mouisel,Nuria Fonknechten,Natacha Roblot,Danielle Seilhean,Andrée Dierich,Jean Jacques Hauw,Judith Melki +13 more
TL;DR: It is the first description of a human neurodegenerative disease which involves this specialized region of the axon and the link between spastin and microtubule dynamics in axons, but not in other neuronal compartments.