N
Nuria Martinez-Lopez
Researcher at Albert Einstein College of Medicine
Publications - 24
Citations - 2030
Nuria Martinez-Lopez is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Autophagy & GNMT. The author has an hindex of 19, co-authored 24 publications receiving 1656 citations. Previous affiliations of Nuria Martinez-Lopez include Newcastle University.
Papers
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Journal ArticleDOI
Autophagy proteins regulate ERK phosphorylation
TL;DR: It is shown that growth factor exposure increases the interaction of ERK cascade components with ATG proteins in the cytosol and nucleus, revealing an unconventional function of AtG proteins as cellular scaffolds in the regulation of ERk phosphorylation.
Journal ArticleDOI
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver
Nuria Martinez-Lopez,Marina García-Macia,Srabani Sahu,Diana Athonvarangkul,Emily Liebling,Paola Merlo,Francesco Cecconi,Gary J. Schwartz,Rajat Singh +8 more
TL;DR: Cold-induced activation of central autophagy activates lipophagy and cytosolic lipases in a complementary manner to mediate lipolysis in peripheral tissues.
Journal ArticleDOI
Autophagy and Lipid Droplets in the Liver
Nuria Martinez-Lopez,Rajat Singh +1 more
TL;DR: In this review, insights into the molecular regulation of lipophagy are provided, fundamental questions related to the mechanisms by which autophagosomes recognize lipid droplets and how ATG proteins regulate membrane curvature for lipid droplet sequestration are discussed, and the possibility of cross talk betweenlipophagy and cytosolic lipases in lipid mobilization is commented on.
Journal ArticleDOI
Autophagy, lipophagy and lysosomal lipid storage disorders
Carl Ward,Nuria Martinez-Lopez,Elsje G. Otten,Bernadette Carroll,Dorothea Maetzel,Rajat Singh,Rajat Singh,Sovan Sarkar,Viktor I. Korolchuk +8 more
TL;DR: The ability of autophagy to contribute to the maintenance of lipo-homeostasis becomes particularly relevant in the context of genetic lysosomal storage disorders where perturbations of Autophagic flux have been suggested to contribution to the disease aetiology.
Book ChapterDOI
Autophagy and Aging
TL;DR: The present chapter describes the two best-characterized autophagy pathways—macroautophagy and chaperone-mediated autophagic, and discusses how changes in these pathways associate with age-associated disorders.