S
Stephan Blüml
Researcher at Medical University of Vienna
Publications - 63
Citations - 3621
Stephan Blüml is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Arthritis & Rheumatoid arthritis. The author has an hindex of 26, co-authored 52 publications receiving 2889 citations. Previous affiliations of Stephan Blüml include Austrian Academy of Sciences.
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Journal ArticleDOI
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Tilmann Bürckstümmer,Christoph Baumann,Stephan Blüml,Stephan Blüml,Evelyn Dixit,Gerhard Dürnberger,Hannah Jahn,Melanie Planyavsky,Martin Bilban,Jacques Colinge,Keiryn L. Bennett,Giulio Superti-Furga +11 more
TL;DR: A systematic proteomics screen for proteins that associate with DNA, 'crossed' to a screen for transcripts induced by interferon-β identified AIM2 as a candidate cytoplasmic DNA sensor for the inflammasome, which showed specificity for double-stranded DNA.
Journal ArticleDOI
Regulation of autoantibody activity by the IL-23-T H 17 axis determines the onset of autoimmune disease.
R Pfeifle,Tobias Rothe,Natacha Ipseiz,Hans Scherer,Stephan Culemann,Ulrike Harre,Jochen A. Ackermann,Martina Seefried,Arnd Kleyer,Stefan Uderhardt,Benjamin Haugg,Axel J. Hueber,Patrick Daum,Gordon F. Heidkamp,Changrong Ge,Sybille Böhm,Anja Lux,Wolfgang Schuh,Iryna Magorivska,Kutty Selva Nandakumar,Erik Lönnblom,Christoph Becker,Diana Dudziak,Manfred Wuhrer,Yoann Rombouts,Yoann Rombouts,Yoann Rombouts,Carolien A. M. Koeleman,René E. M. Toes,Thomas Winkler,Rikard Holmdahl,Martin Herrmann,Stephan Blüml,Falk Nimmerjahn,Georg Schett,Gerhard Krönke +35 more
TL;DR: An IL-23–TH17 cell–dependent pathway is identified that controls autoantibody activity and unmasks a preexisting breach in immunotolerance in rheumatoid arthritis.
Journal ArticleDOI
Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice.
Stephan Blüml,Michael Bonelli,Birgit Niederreiter,Antonia Puchner,Georg Mayr,Silvia Hayer,Marije I. Koenders,Wim B. van den Berg,Josef S Smolen,Kurt Redlich +9 more
TL;DR: It is demonstrated that miR-155 is essentially involved in the adaptive and innate immune reactions leading to autoimmune arthritis, and therefore mi R-155 might provide a novel target for the treatment of patients with RA.
Journal ArticleDOI
CD14 is a coreceptor of Toll-like receptors 7 and 9
Christoph Baumann,Irene M. Aspalter,Omar Sharif,Andreas Pichlmair,Stephan Blüml,Florian Grebien,Manuela Bruckner,Pawel Pasierbek,Karin Aumayr,Melanie Planyavsky,Keiryn L. Bennett,Jacques Colinge,Sylvia Knapp,Giulio Superti-Furga +13 more
TL;DR: CD14 interacts with and is essential for the functions of endosomal TLR7 and TLR9 in mice and acts as a “spatially aggregating force” to spruce up the immune response to chemotherapy.
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SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity.
Daniel Mrak,Selma Tobudic,Maximilian Koblischke,Marianne Graninger,Helga Radner,Daniela Sieghart,Philipp Hofer,Thomas Perkmann,Helmuth Haslacher,Renate Thalhammer,Stefan Winkler,Stephan Blüml,Karin Stiasny,Judith H. Aberle,Josef S Smolen,Leonhard X. Heinz,Daniel Aletaha,Michael Bonelli +17 more
TL;DR: In this article, SARS-CoV-2-specific T-cell responses were quantified by IFNγ enzyme-linked immunosorbent spot assays using the Elecsys Anti-SARS CoV2 S immunoassay against the receptor-binding domain (RBD) of the spike protein and neutralisation tests.