M
Mathias Müller
Researcher at University of Veterinary Medicine Vienna
Publications - 357
Citations - 18828
Mathias Müller is an academic researcher from University of Veterinary Medicine Vienna. The author has contributed to research in topics: Tyrosine kinase 2 & Janus kinase. The author has an hindex of 65, co-authored 347 publications receiving 17042 citations. Previous affiliations of Mathias Müller include University of Veterinary Science & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis
TL;DR: The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis.
Journal ArticleDOI
The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
Thomas Weichhart,Giuseppina Costantino,Marko Poglitsch,Margit Rosner,Maximilian Zeyda,Karl M. Stuhlmeier,Thomas Kolbe,Thomas M. Stulnig,Walter H. Hörl,Markus Hengstschläger,Mathias Müller,Marcus D. Säemann +11 more
TL;DR: It is shown that the tuberous sclerosis complex-mammalian target of rapamycin (TSC-mTOR) pathway regulated inflammatory responses after bacterial stimulation in monocytes, macrophages, and primary dendritic cells, and protected genetically susceptible mice against lethal Listeria monocytogenes infection.
Journal ArticleDOI
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
Mathias Müller,James Briscoe,Carl D. Laxton,Dmitry Guschin,Andrew Ziemiecki,Olli Silvennoinen,Ailsa G. Harpur,Giovanna Barbieri,Bruce A. Witthuhn,Chris Schindler,Sandra Pellegrini,Andrew F. Wilks,James N. Ihle,George R. Stark,lan M. Kerr +14 more
TL;DR: A cell line is produced which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response, but implementation of this mutant with JAK2 restored the response, establishing the requirement for JAK 1 in both the interferons-& alpha;/&# 38; beta; and -& #38; gamma; signal transduction pathways.
Journal ArticleDOI
The Yin and Yang of type I interferon activity in bacterial infection
TL;DR: An increasing body of work shows that type I IFNs have an important role in the host response to bacterial infection, and can influence various immune effector mechanisms.
Journal ArticleDOI
IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA
Andreas Pichlmair,Caroline Lassnig,Carol-Ann Eberle,Maria W. Górna,Christoph Baumann,Thomas R Burkard,Tilmann Bürckstümmer,Adrijana Stefanovic,Sigurd Krieger,Keiryn L. Bennett,Thomas Rülicke,Friedemann Weber,Jacques Colinge,Mathias Müller,Giulio Superti-Furga +14 more
TL;DR: It is proposed that the IFIT complex antagonizes viruses by sequestering specific viral nucleic acids through its binding to PPP-RNA.