O. Chappey

TL;DR: Findings underscore a central role of NADPH oxidase in AGE-RAGE-mediated generation of ROS and provide a mechanism for altered gene expression in A GE-related disorders.

TL;DR: Data support the concept that ligation of AGEs by endothelial RAGE induces cellular dysfunction, at least in part by an oxidant-sensitive mechanism, contributing to vascular hyperpermeability in diabetes, and that RAGE is central to this pathologic process.

TL;DR: In this article, the authors hypothesized that formation of advanced glycation end products (AGEs) on the surface of diabetic erythrocytes could mediate their interaction with ECs leading to binding and induction of vascular dysfunction.

TL;DR: An attempt to minimize AGE formation and to limit ROI production by an appropriate therapy may result in the reduction or slowing of vascular disease in patients with diabetes mellitus.

TL;DR: This study showed that rR-RAGE was biologically active in vivo and slowly cleared, which suggests it could be considered as a potential therapy in patients with diabetes mellitus.