O
O Klymenko
Researcher at University of Giessen
Publications - 10
Citations - 151
O Klymenko is an academic researcher from University of Giessen. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 5 publications receiving 97 citations.
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Journal ArticleDOI
Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.
Martina Korfei,S Skwarna,Ingrid Henneke,BreAnne MacKenzie,O Klymenko,Shigeki Saito,Clemens Ruppert,Daniel von der Beck,Poornima Mahavadi,Walter Klepetko,Saverio Bellusci,Bruno Crestani,Soni Savai Pullamsetti,Ludger Fink,Werner Seeger,Oliver H. Krämer,Andreas Guenther +16 more
TL;DR: Aberrant overexpression of HDACs in basal cells of IPF lungs may contribute to the bronchiolisation process in this disease and pan-HDAC inhibition by LBH589 may present a novel therapeutic option for patients with IPF.
Journal ArticleDOI
Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells.
O Klymenko,Martin Huehn,Jochen Wilhelm,Roxana Wasnick,Irina Shalashova,Clemens Ruppert,Ingrid Henneke,Stefanie Hezel,Katharina Guenther,Poornima Mahavadi,Christos Samakovlis,Werner Seeger,Andreas Guenther,Martina Korfei +13 more
TL;DR: It is proposed that CHOP activation by AP-1 and c-Ets-1 plays a key role in AECII maladaptive ER stress responses and consecutive fibrosis, offering new therapeutic prospects in IPF.
Posted ContentDOI
Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition
Roxana Wasnick,Martina Korfei,K Piskulak,Ingrid Henneke,Jochen Wilhelm,Poornima Mahavadi,D der Beck von,M. Koch,Irina Shalashova,O Klymenko,Ludger Fink,Heiko Witt,Holger Hackstein,E Agha El,Saverio Bellusci,Walter Klepetko,Melanie Königshoff,Melanie Königshoff,Oliver Eickelberg,Oliver Eickelberg,Thomas Braun,Werner Seeger,Clemens Ruppert,Andreas Guenther +23 more
TL;DR: Inhibition of Notch signaling in cultured human IPF precision cut lung slices improved surfactant processing capacity of AEC2s and reversed fibrosis, and Notch1 therefore offers as novel therapeutic target.
Journal ArticleDOI
Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis.
Roxana Wasnick,Martina Korfei,Katarzyna Piskulak,Ingrid Henneke,Jochen Wilhelm,Poornima Mahavadi,Ruth C. Dartsch,D. von der Beck,M. Koch,Irina Shalashova,Astrid Weiss,O Klymenko,I. Askevold,Ludger Fink,Heiko Witt,Holger Hackstein,Elie El Agha,Saverio Bellusci,Walter Klepetko,Melanie Königshoff,Oliver Eickelberg,Ralph T. Schermuly,Thomas Braun,Werner Seeger,Clemens Ruppert,Andreas Guenther +25 more
TL;DR: Notch1 is a central regulator of AEC2 fate in IPF and induces alveolar epithelial proliferation, loss of Napsin A and of surfactant proprotein processing and it contributes to fibroproliferation.
Journal ArticleDOI
Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life
Jaco Selle,Katharina Dinger,Vanessa Jentgen,Daniela Zanetti,Johannes Will,Theodoros Georgomanolis,Christina Vohlen,Rebecca Wilke,Baktybek Kojonazarov,O Klymenko,Jasmine Mohr,Silke V Koningsbruggen-Rietschel,Christopher J. Rhodes,Anna Ulrich,Dharmesh Hirani,Tim Nestler,Margarete Odenthal,Esther Mahabir,S. Nayakanti,Swati Dabral,Thomas F. Wunderlich,James R. Priest,Werner Seeger,Jörg Dötsch,Soni Savai Pullamsetti,Miguel A. Alejandre Alcazar +25 more
TL;DR: In this paper , the interleukin-6-FoxO1 pathway was found to be a molecular mechanism by which perinatal obesity programs the bronchial and vascular structure and function, thereby driving chronic lung diseases.