Roxana Wasnick

TL;DR: The authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts.

TL;DR: Strong expression of F GF1/FGFRs in pathogenic regions of IPF suggest that aberrant FGF1-FGFR signaling is increased in IPF patients and may contribute to the pathogenesis of lung fibrosis by supporting fibroblast migration and increased MAPK-signaling.

TL;DR: It is reported that inactivation of Fgfr2b in BESCs impairs their contribution to both alveolar epithelial regeneration and honeycomb cysts after bleomycin injury, which enhances fibrosis resolution by favoring the more desirable outcome of alve solar epithelium regeneration over the development of pathologic honeycomb Cysts.

TL;DR: In this paper, the effect of exogenous ligands on human lung fibroblasts was evaluated using western blotting and qPCR for FGF1 and FGFR1/2/3/4.

TL;DR: TYKRIL plays an important role in PAH by regulating the p53/PDGFRβ axis as well as binding to the N-terminal of p53 and interfering with p53-p300 interaction that regulates p53 nuclear translocation.