Ole H. Petersen

TL;DR: The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) have been updated and information reorganised to facilitate their use in practice to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

TL;DR: The ARRIVE guidelines are revised to update them and facilitate their use in practice and this explanation and elaboration document was developed as part of the revision.

TL;DR: Three kinds of membrane potassium channels activated by intracellular calcium ions in animal cells are characterized by the patch-clamp technique, playing a crucial part in the regulation of membrane potential and of secretion.

TL;DR: It is shown that neither Ins P3 alone nor Ins P4 alone can activate a sustained current, whereas inositol 1,3,4,5-tetrakisphosphate in combination in combination evoke a sustained increase in Ca2+-activated K+ current which is dependent on external Ca2+.

TL;DR: It is demonstrated that low (physiological) agonist concentrations evoke local cytosolic Ca2+ spikes in the secretory pole of single mouse pancreatic acinar cells that are particularly sensitive to blockade by the IP3 receptor antagonist heparin.