Olga Protchenko

TL;DR: Iron is an essential nutrient for almost every organism because iron cofactors, such as heme and iron-sulfur clusters (ISC), are required for the activity of numerous cellular enzymes involved in a wide range of cellular processes.

TL;DR: A two-stage iron-dependent mechanism for iron in ferroptosis is proposed by combining its catalytic role in the 15-LOX-driven production of 15-hydroperoxy-AA-PE (HOO-AA -PE) as well as possible involvement of loosely-bound iron in oxidative cleavage of HOO- AA-PE to oxidatively truncated electrophiles capable of attacking nucleophilic targets in yet to be identified proteins leading to cell demise.

TL;DR: FIT-deletion strains exhibited increased expression of Aft1p target genes as measured by a FET3-lacZreporter gene or by Arn1p Western blotting, indicating that cells respond to the absence of FIT genes by up-regulating systems of iron uptake.

TL;DR: The functional interactions between VDAC and α- Synuclein point toward the long sought after physiological and pathophysiological roles for monomeric α-syn in PD and in other α- synucleinopathies.

TL;DR: Iron-deficient cells exhibited depletion of most iron enzyme activities, but loss of activity during iron deficiency did not consistently disrupt metabolism, and Amino acid homeostasis was robust, but iron deficiency impaired lipid synthesis, altering the properties and functions of cellular membranes.