O
Olga Samsonova
Researcher at University of Marburg
Publications - 13
Citations - 592
Olga Samsonova is an academic researcher from University of Marburg. The author has contributed to research in topics: Polymer & Dynamic light scattering. The author has an hindex of 10, co-authored 13 publications receiving 546 citations.
Papers
More filters
Journal ArticleDOI
Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery.
TL;DR: Amphiphilic PEG-PCL-PEI triblock copolymers self-assemble into nano-scaled, positively charged, multifunctional carriers, suitable for drug and gene delivery and a promising candidate for prospective co-delivery of drugs and nucleic acids.
Journal ArticleDOI
Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity.
Olivia M. Merkel,Meredith A. Mintzer,Damiano Librizzi,Olga Samsonova,Tanja Dicke,Brian S. Sproat,Holger Garn,Peter Barth,Eric E. Simanek,Thomas Kissel +9 more
TL;DR: The ability to correlate the effects of triazine dendrimer core scaffolds, generation number, and surface functionality with siRNA transfection efficiency yields valuable information for further modifying this nonviral delivery system and stresses the importance of only loosely correlating effective gene delivery vectors with si RNA transfections agents.
Journal ArticleDOI
Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene Delivery Agents?
TL;DR: These diblock-copolymers showed enhanced transfection efficacy under in vitro conditions due to their lower cytotoxicity, efficient cellular uptake and DNA packaging, implying a crucial impact of pHEMA on vector-cell interactions.
Journal ArticleDOI
Biophysical characterization of hyper-branched polyethylenimine-graft-polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery.
TL;DR: It was found that longer mPEG chains, longer PCL segments and higher graft density beneficially affected the stability and formation ofpolyplexes and reduced the zeta-potential of siRNA polyplexes.
Journal ArticleDOI
Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density.
TL;DR: It was found that the transfection efficiencies of these polymers increased at first towards an optimal graft density and then decreased, and the buffer-capacity-test showed almost exactly the same tendency as transfections efficiency.