O
Oliver McConnell
Researcher at Princeton University
Publications - 11
Citations - 1460
Oliver McConnell is an academic researcher from Princeton University. The author has contributed to research in topics: Ion & Chiral resolution. The author has an hindex of 11, co-authored 11 publications receiving 1297 citations.
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High throughput artificial membrane permeability assay for blood-brain barrier
TL;DR: A modification of the parallel artificial membrane permeation assay (PAMPA), developed with 30 structurally diverse commercial drugs and validated with 14 Wyeth Research compounds, has the advantages of predicting passive blood-brain barrier penetration with high success, high throughput, low cost, and reproducibility.
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Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates.
TL;DR: Optimization of a simple, robust, high-throughput microsomal stability assay developed in a 96-well format to meet the increasing demand of throughput, speed, and reproducibility at earlier stages of drug discovery.
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Advantages of atmospheric pressure photoionization mass spectrometry in support of drug discovery
TL;DR: APPI could be considered a more universal ionization method, and therefore has great potential in high-throughput drug discovery especially for open access liquid chromatography/mass spectrometry (LC/MS) applications.
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Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography-mass spectrometry.
Edward H. Kerns,Li Di,Susan Petusky,Teresa Kleintop,Donna M. Huryn,Oliver McConnell,Guy T. Carter +6 more
TL;DR: A method is described for the simultaneous profiling of sample lipophilicity, integrity, and purity and is applicable to high throughput profiling of pharmaceutical properties in drug discovery.
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Enhanced chromatographic resolution of amine enantiomers as carbobenzyloxy derivatives in high-performance liquid chromatography and supercritical fluid chromatography.
TL;DR: Improved selectivity and resolution combined with an automated preparative HPLC or SFC system can lead to the rapid generation of highly purified enantiomers of desirable starting materials, intermediates or final products.