Showing papers by "Olivier Bernard published in 1987"
TL;DR: Sixty‐five patients with histologically proven chronic active hepatitis of unknown cause but associated with the antiliver/kidney microsome antibody type 1, confirmed by immunofluorescence and immunoprecipitation, were selected as forming a special entity.
527 citations
TL;DR: The incidence of signs of portal hypertension in children with normal serum bilirubin values at age 5 years was not higher in those who had previously experienced one or more episodes of cholangitis.
75 citations
73 citations
TL;DR: Eight children with cholestasis from the first week of life, followed by early cirrhosis and portal hypertension, are described and abnormal intrahepatic bile ducts with rarefaction of segmental branches, stenosis, and focal dilation are disclosed.
62 citations
TL;DR: Plasma lipid peroxide levels were studied in 40 children with chronic cholestasis comprising 21 with syndromatic paucity of interlobular bile ducts (PILBD) and 19 with biliary atresia, and Vitamin E treatment seemed to have no effect on these increased cholesterol, cholesterol and phospholipid concentrations.
Abstract: Plasma lipid peroxide levels were studied in 40 children with chronic cholestasis comprising 21 with syndromatic paucity of interlobular bile ducts (PILBD) and 19 with biliary atresia. Compared to the controls, mean lipid peroxide values were twice as high in children with biliary atresia (4.56 +/- 2.28 nmol/ml) and four times as high in those with PILBD (9.62 +/- 3.3 nmol/ml). These differences are highly significant. In patients with biliary atresia, the increase in lipid peroxide levels was clearly related to the bilirubin, cholesterol and phospholipid concentrations. In the PILBD group, however, there was little evidence of such a relationship. Vitamin E treatment seemed to have no effect on these increased lipid peroxide levels during the evolution of chronic cholestasis, and further investigations are necessary to clarify the pathological mechanisms involved.
32 citations
TL;DR: Bile ducts size returned to normal in all patients who are clinical well with a follow-up from 1 to 6 years.
Abstract: Twelve patients (11 girls and 1 boy) with di- lated bile ducts and anomalous junction between the common bile duct and pancreatic duct are reported. All patients underwent preoperative opacification of the bile ducts either by transhepatic cholangiography or percutaneous cholecystography. Abdominal pain and jaundice were the main clinical symptoms. Re- flux of pancreatic enzymes in the bile duct was prov- en by measuring amylase and lipase activity in the biliary system after IV injection of 1 IU/kg of chole- cystokinin. All patients were operated upon. Bile ducts size returned to normal in all patients who are clinical well with a follow-up from I to 6 years.
9 citations
TL;DR: Bile ducts size returned to normal in all patients who are clinical well with a follow-up from 1 to 6 years.
Abstract: Twelve patients (11 girls and 1 boy) with dilated bile ducts and anomalous junction between the common bile duct and pancreatic duct are reported. All patients underwent preoperative opacification of the bile ducts either by transhepatic cholangiography or percutaneous cholecystography. Abdominal pain and jaundice were the main clinical symptoms. Reflux of pancreatic enzymes in the bile duct was proven by measuring amylase and lipase activity in the biliary system after IV injection of 1 IU/kg of cholecystokinin. All patients were operated upon. Bile ducts size returned to normal in all patients who are clinical well with a follow-up from 1 to 6 years.
8 citations
2 citations
TL;DR: There is no difference between children and adult populations, and no correlation either the type of liver disease or presence of HBV DNA in the serum, which indicates that the DNA detected in human mononuclear cells is transcriptionnally active.
Abstract: 63. DETECTION OF LYMPHOCYTES EXPRESSING HEPATITIS B VIRUS IN PERIPHERAL BLOOD FROM HBsAg POSITIVE AND NEGATIVE CHILDREN AND ADULTS BY “IN SITU” HYBRIDIZATION
1 citations