O
Olivier Pascual
Researcher at Claude Bernard University Lyon 1
Publications - 29
Citations - 3219
Olivier Pascual is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Hypoxia (medical) & Neurotransmission. The author has an hindex of 15, co-authored 25 publications receiving 2953 citations. Previous affiliations of Olivier Pascual include University of Pennsylvania & Centre national de la recherche scientifique.
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Journal ArticleDOI
Astrocytic purinergic signaling coordinates synaptic networks.
Olivier Pascual,Kristen B. Casper,Cathryn Kubera,Jing Zhang,Raquel Revilla-Sanchez,Jai Yoon Sul,Hajime Takano,Stephen J. Moss,Ken D. McCarthy,Philip G. Haydon +9 more
TL;DR: The results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk.
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Neuronal Synchrony Mediated by Astrocytic Glutamate through Activation of Extrasynaptic NMDA Receptors
TL;DR: The results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors.
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Synaptotagmin IV regulates glial glutamate release
TL;DR: The finding that Syt IV is expressed predominantly by astrocytes and is not in the presynaptic terminals of the hippocampus, and because SytIV knockout mice exhibit hippocampal-based memory deficits, raises the intriguing possibility that SyT IV-mediated gliotransmission contributes to hippocampus-dependent memory.
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Adenosine released by astrocytes contributes to hypoxia‐induced modulation of synaptic transmission
Eduardo D. Martín,Miriam Fernández,Gertrudis Perea,Olivier Pascual,Philip G. Haydon,Alfonso Araque,Valentín Ceña +6 more
TL;DR: It is concluded that during hypoxia, astrocytes contribute to regulate the excitatory synaptic transmission through the release of adenosine, which acting on A1Adenosine receptors reduces presynaptic transmitter release and serves as a protective mechanism by down regulating the synaptic activity level during demanding conditions such as transient Hypoxia.
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Astrocytes Coordinate Synaptic Networks: Balanced Excitation and Inhibition
TL;DR: Although neurons are essential for brain function, an emerging alternative view holds that astrocytes, the dominant glial cell type, coordinate synaptic networks.