Tommaso Fellin

TL;DR: The results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors.

TL;DR: In this article, targeted molecular genetic approaches that have demonstrated that alterations in protein expression in astrocytes can lead to serious changes in neuronal function were discussed, and the concept of "astrocyte activation spectrum" was introduced, in which enhanced and reduced gliotransmission might contribute to epilepsy and schizophrenia.

TL;DR: It is concluded that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors.

TL;DR: A new structurally based conceptual framework is offered to evaluate functional data involving interactions between neurons and astrocytes in the mammalian brain by proposing the concept of functional islands of synapses in which groups of synapse confined within the boundaries of an individualAstrocyte are modulated by the gliotransmitter environment controlled by that astroCyte.

TL;DR: The data show that mutational changes of functional channel densities can be different in different cell types, and they uncover two functional effects common to all FHM mutations analyzed: increase of single-channel Ca2+ influx and decrease of maximal CaV2.1 current density in neurons.