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Olle Melander

Researcher at Lund University

Publications -  854
Citations -  90230

Olle Melander is an academic researcher from Lund University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 109, co-authored 783 publications receiving 75911 citations. Previous affiliations of Olle Melander include National Institutes of Health & Malmö University.

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High pro‑neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow‑up

TL;DR: In this paper, a longitudinal retrospective study was conducted to evaluate plasma pro-NT in type 1 diabetes patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile.
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Letter by Schomburg and Melander Regarding Article, "Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target".

TL;DR: This fascinating report is characterized by a selection of most appropriate in vitro and in vivo models combined with high-quality analytical techniques and a scholarly performed discussion, but the SELENOP concentrations reported appear unphysiologically high.
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New Insights in the Control of Fat Homeostasis: The Role of Neurotensin

TL;DR: This review aims to provide a synthetic overview of the main regulatory effects of NT on several biological pathways, particularly those involving energy balance, and will focus on new evidence on the role of NT in controlling fat homeostasis, thus influencing the risk of unfavorable cardio–metabolic outcomes and overall mortality in humans.
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Analysis of Low Frequency Protein Truncating Stop-Codon Variants and Fasting Concentration of Growth Hormone.

TL;DR: It is suggested that a stop codon of Myosin 1A, disrupting 91% of the predicted amino acid sequence, is associated with higher hs-GH and GH-related traits suggesting that MYO1A is involved in GH metabolism and possibly body fat distribution, however, results are preliminary and need replication in independent populations.