O
Omer N. Koc
Researcher at Cleveland Clinic
Publications - 36
Citations - 2853
Omer N. Koc is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Bone marrow & Transplantation. The author has an hindex of 16, co-authored 36 publications receiving 2788 citations. Previous affiliations of Omer N. Koc include University Hospitals of Cleveland & Case Western Reserve University.
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Journal ArticleDOI
Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH).
TL;DR: Donor allogeneic MSC infusion is safe and may be associated with reversal of disease pathophysiology in some tissues and the role of MSCs in the management of Hurler syndrome and MLD should be further evaluated.
Journal ArticleDOI
Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation
Basabi Maitra,Emese Szekely,K Gjini,Mary J. Laughlin,James E. Dennis,Stephen E. Haynesworth,Omer N. Koc +6 more
TL;DR: Preclinical data suggest that unrelated, human bone marrow-derived, culture-expanded MSCs may improve the outcome of allogeneic transplantation by promoting hematopoietic engraftment and limiting GVHD and their therapeutic potential should be tested in clinic.
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Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells.
TL;DR: It is found that CD14+ monocytes from blood activate MSCs to secrete inhibitory molecules that lead to inhibition of alloreactive T cells, which represents a unique immune regulatory paradigm that can potentially be exploited in clinic.
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Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases
Omer N. Koc,Charles Peters,Patrick Aubourg,Shrini Raghavan,Stephanie M. Dyhouse,Rita DeGasperi,Edwin H. Kolodny,Yoav Ben-Yoseph,Stanton L. Gerson,Hillard M. Lazarus,Arnold I. Caplan,Paul A. Watkins,William Krivit +12 more
TL;DR: It is found that MSCs isolated from recipients of allogeneic HSC transplantation are not of donor genotype and have persistent phenotypic defects despite successful donor type hematopoietic engraftment, raising the possibility that M SCs may be useful in the treatment of storage disorders.
Journal ArticleDOI
Mesenchymal stem cells: heading into the clinic.
Omer N. Koc,Hillard M. Lazarus +1 more
TL;DR: The current understanding of bone marrow stroma and MSCs is reviewed and their potential therapeutic role in the setting of hematopoietic stem cell transplantation is reviewed.