O
Ophelia Papoulas
Researcher at University of California, Santa Cruz
Publications - 17
Citations - 1546
Ophelia Papoulas is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Biology & Chromatin remodeling. The author has an hindex of 10, co-authored 10 publications receiving 1471 citations.
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Journal ArticleDOI
The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.
Renate Deuring,Laura Fanti,Laura Fanti,Jennifer A. Armstrong,Melinda Sarte,Ophelia Papoulas,Matthias Prestel,Gary Daubresse,Megan Verardo,Sarah L. Moseley,Maria Berloco,Maria Berloco,Toshio Tsukiyama,Carl Wu,Sergio Pimpinelli,John W. Tamkun +15 more
TL;DR: It is found that ISWI mutations affect both cell viability and gene expression during Drosophila development and cause striking alterations in the structure of the male X chromosome.
Journal ArticleDOI
The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes
Ophelia Papoulas,Shelley J. Beek,Sarah L. Moseley,Claire M. McCallum,Melinda Sarte,Allen Shearn,John W. Tamkun +6 more
TL;DR: The trithorax group gene brahma (brm) encodes an activator of Drosophila homeotic genes that functions as the ATPase subunit of a large protein complex as discussed by the authors.
Journal ArticleDOI
Genetic analysis of brahma: The drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2
Lisa K. Elfring,Carla Daniel,Ophelia Papoulas,Renate Deuring,Melinda Sarte,Sarah L. Moseley,Shelley J. Beek,W. Ross Waldrip,Gary Daubresse,Angela H. DePace,James A. Kennison,John W. Tamkun +11 more
TL;DR: It is found that the complete loss of brm function decreases cell viability and causes defects in the peripheral nervous system of the adult and site-directed mutagenesis was used to investigate the functions of conserved regions of the BRM protein.
Journal ArticleDOI
The Drosophila BRM complex facilitates global transcription by RNA polymerase II.
Jennifer A. Armstrong,Ophelia Papoulas,Gary Daubresse,Adam S. Sperling,John T. Lis,Matthew P. Scott,John W. Tamkun +6 more
TL;DR: Examination of the distribution of the BRM complex on larval salivary gland polytene chromosomes suggests that the chromatin remodeling activity of theBRM complex plays a general role in facilitating transcription by RNA polymerase II.
Journal ArticleDOI
The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity.
Gary Daubresse,Renate Deuring,L. Moore,Ophelia Papoulas,I. Zakrajsek,W.R. Waldrip,Matthew P. Scott,J.A. Kennison,John W. Tamkun +8 more
TL;DR: The Drosophila kismet gene encodes several large nuclear proteins that are ubiquitously expressed along the anterior-posterior axis, providing further evidence that alterations in chromatin structure are required to maintain the spatially restricted patterns of homeotic gene transcription.