The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.
Renate Deuring,Laura Fanti,Laura Fanti,Jennifer A. Armstrong,Melinda Sarte,Ophelia Papoulas,Matthias Prestel,Gary Daubresse,Megan Verardo,Sarah L. Moseley,Maria Berloco,Maria Berloco,Toshio Tsukiyama,Carl Wu,Sergio Pimpinelli,John W. Tamkun +15 more
TLDR
It is found that ISWI mutations affect both cell viability and gene expression during Drosophila development and cause striking alterations in the structure of the male X chromosome.About:
This article is published in Molecular Cell.The article was published on 2000-02-01 and is currently open access. It has received 421 citations till now. The article focuses on the topics: Chromatin remodeling & ATP-dependent chromatin remodeling.read more
Citations
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Journal ArticleDOI
The Biology of Chromatin Remodeling Complexes
TL;DR: This work addresses many aspects of remodeler biology: their targeting, mechanism, regulation, shared and unique properties, and specialization for particular biological processes.
Journal ArticleDOI
Cooperation between Complexes that Regulate Chromatin Structure and Transcription
TL;DR: How the activities of two major classes of chromatin-modifying complexes, ATP-dependent remodeling complexes and HAT or HDAC complexes might be coordinated to create a DNA template that is accessible to the general transcription apparatus is discussed.
Journal ArticleDOI
Chromatin remodelling during development
Lena Ho,Gerald R. Crabtree +1 more
TL;DR: New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms, and particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.
Journal ArticleDOI
ATP-Dependent Nucleosome Remodeling
Peter B. Becker,Wolfram Hörz +1 more
TL;DR: Recent progress is summarized in the understanding of the mechanisms underlying the nucleosome remodeling reaction, the targeting of remodeling machines to selected sites in chromatin, and their integration into complex regulatory schemes.
Journal ArticleDOI
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
TL;DR: The mechanistic bases underlying the genetic requirements for BAF and other chromatin remodelers in development and cancer are relatively unexplored and will be a focus of this review.
References
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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
Andrea H. Brand,Norbert Perrimon +1 more
TL;DR: The GAL4 system, a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns, has been designed and used to expand the domain of embryonic expression of the homeobox protein even-skipped.
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Book
The Genome of Drosophila Melanogaster
TL;DR: Chromosomes: Deficiencies, Inversions, and Transposable Elements.
Journal ArticleDOI
Analysis of genetic mosaics in developing and adult Drosophila tissues
Tian Xu,Gerald M. Rubin +1 more
TL;DR: This work has constructed a series of strains to facilitate the generation and analysis of clones of genetically distinct cells in developing and adult tissues of Drosophila, providing an unprecedented opportunity to perform systematic genetic screens for mutations affecting many biological processes.
Journal ArticleDOI
Structure and ligand of a histone acetyltransferase bromodomain
TL;DR: The solution structure of the bromodomain of the HAT co-activator P/CAF (p300/CBP-associated factor) reveals an unusual left-handed up-and-down four-helix bundle, and it is shown by a combination of structural and site-directed mutagenesis studies that bromidomains can interact specifically with acetylated lysine, making them the first known protein modules to do so.