A
Adam S. Sperling
Researcher at Harvard University
Publications - 67
Citations - 3062
Adam S. Sperling is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 44 publications receiving 2097 citations. Previous affiliations of Adam S. Sperling include Massachusetts Institute of Technology & Broad Institute.
Papers
More filters
Journal ArticleDOI
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
Niccolo Bolli,Hervé Avet-Loiseau,David C. Wedge,Peter Van Loo,Ludmil B. Alexandrov,Inigo Martincorena,Kevin J. Dawson,Francesco Iorio,Serena Nik-Zainal,Graham R. Bignell,Jonathan Hinton,Yang Li,Jose M. C. Tubio,Stuart McLaren,Sarah O' Meara,Adam Butler,Jon W. Teague,Laura Mudie,Elizabeth Anderson,Naim U. Rashid,Yu-Tzu Tai,Masood A. Shammas,Adam S. Sperling,Mariateresa Fulciniti,Paul G. Richardson,Giovanni Parmigiani,Florence Magrangeas,Stephane Minvielle,Philippe Moreau,Michel Attal,Thierry Facon,P. Andrew Futreal,Kenneth C. Anderson,Peter J. Campbell,Nikhil C. Munshi +34 more
TL;DR: The myeloma genome is heterogeneous across the cohort, and exhibits diversity in clonal admixture and in dynamics of evolution, which may impact prognostic stratification, therapeutic approaches and assessment of disease response to treatment.
Journal ArticleDOI
The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia.
TL;DR: The molecular processes that lead to CHIP and further clonal evolution to MDS and sAML are discussed, and the ways in which these insights are shaping the clinical management of MDS are highlighted, including classification schemata, prognostic scoring systems and therapeutic approaches.
Journal ArticleDOI
Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Wei Xie,Chunying Song,Nicolas L. Young,Adam S. Sperling,Feng Xu,Rupa Sridharan,Anne E. Conway,Benjamin A. Garcia,Kathrin Plath,Amander T. Clark,Michael Grunstein +10 more
TL;DR: The results suggest that K56Ac is involved in the human core transcriptional network of pluripotency, and more accurately reflects the epigenetic differences between hESCs and somatic cells than other active histone marks such as H3 K4 trimethylation and K9 acetylation.
Journal ArticleDOI
The Drosophila BRM complex facilitates global transcription by RNA polymerase II.
Jennifer A. Armstrong,Ophelia Papoulas,Gary Daubresse,Adam S. Sperling,John T. Lis,Matthew P. Scott,John W. Tamkun +6 more
TL;DR: Examination of the distribution of the BRM complex on larval salivary gland polytene chromosomes suggests that the chromatin remodeling activity of theBRM complex plays a general role in facilitating transcription by RNA polymerase II.
Journal ArticleDOI
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Mikolaj Slabicki,Mikolaj Slabicki,Mikolaj Slabicki,Zuzanna Kozicka,Zuzanna Kozicka,Georg Petzold,Yen-Der Li,Yen-Der Li,Manisha Manojkumar,Manisha Manojkumar,Manisha Manojkumar,Richard D. Bunker,Katherine A. Donovan,Quinlan L. Sievers,Quinlan L. Sievers,Jonas Koeppel,Jonas Koeppel,Jonas Koeppel,Dakota Suchyta,Dakota Suchyta,Adam S. Sperling,Adam S. Sperling,Emma C. Fink,Emma C. Fink,Jessica A. Gasser,Jessica A. Gasser,Li R. Wang,Steven M. Corsello,Steven M. Corsello,Rob S. Sellar,Rob S. Sellar,Rob S. Sellar,Max Jan,Max Jan,Dennis Gillingham,Claudia Scholl,Stefan Fröhling,Todd R. Golub,Todd R. Golub,Todd R. Golub,Eric S. Fischer,Nicolas H. Thomä,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +44 more
TL;DR: It is demonstrated that chemical alteration of surface-exposed moieties can confer gain-of-function glue properties to an inhibitor, and this is proposed as a broader strategy through which target-binding molecules could be converted into molecular glues.