Ophelia Papoulas

TL;DR: It is found that ISWI mutations affect both cell viability and gene expression during Drosophila development and cause striking alterations in the structure of the male X chromosome.

TL;DR: The trithorax group gene brahma (brm) encodes an activator of Drosophila homeotic genes that functions as the ATPase subunit of a large protein complex as discussed by the authors.

TL;DR: It is found that the complete loss of brm function decreases cell viability and causes defects in the peripheral nervous system of the adult and site-directed mutagenesis was used to investigate the functions of conserved regions of the BRM protein.

TL;DR: Examination of the distribution of the BRM complex on larval salivary gland polytene chromosomes suggests that the chromatin remodeling activity of theBRM complex plays a general role in facilitating transcription by RNA polymerase II.

TL;DR: The Drosophila kismet gene encodes several large nuclear proteins that are ubiquitously expressed along the anterior-posterior axis, providing further evidence that alterations in chromatin structure are required to maintain the spatially restricted patterns of homeotic gene transcription.