O
Ora Bernard
Researcher at St. Vincent's Institute of Medical Research
Publications - 87
Citations - 8249
Ora Bernard is an academic researcher from St. Vincent's Institute of Medical Research. The author has contributed to research in topics: Lim kinase & Cofilin. The author has an hindex of 42, co-authored 87 publications receiving 7984 citations. Previous affiliations of Ora Bernard include St. Vincent's Health System & University of Melbourne.
Papers
More filters
Journal ArticleDOI
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
Silvia Arber,Freda A. Barbayannis,Hartwig Hanser,Corinna Schneider,Clement A. Stanyon,Ora Bernard,Pico Caroni +6 more
TL;DR: A mechanism for the regulation of cofilin and hence of actin dynamics in vivo is defined and should play a central role in regulating cell motility and morphogenesis by modulating the stability of act in cytoskeletal structures.
Journal ArticleDOI
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
TL;DR: It is shown that neurons rescued from NGF withdrawal-induced apoptosis by expression of dominant-negative c-Jun do not release cytochrome c from their mitochondria, and neurons injected with Bim antisense oligonucleotides or isolated from Bim(-/-) knockout mice die more slowly after NGF withdraw.
Journal ArticleDOI
Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain
TL;DR: The sequence confirms that the variable region gene lies on the DNA separated from the constant region of a mouse immunoglobulin light chain, the VlambdaII gene, andHypervariable region codons appear in the germ-line sequence.
Journal ArticleDOI
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
Victoria C. Foletta,Mei Ann Lim,Juliana Soosairajah,April P. Kelly,Edouard G. Stanley,Mark Shannon,Wei He,Supratik Das,Joan Massagué,Ora Bernard +9 more
TL;DR: This study identifies the first function of the BMPR-II tail domain and suggests that the deregulation of actin dynamics may contribute to the etiology of PPH.
Journal ArticleDOI
Lim kinases, regulators of actin dynamics
TL;DR: LIMK1 was shown to be involved in cancer metastasis, while LIMK2 activation promotes cells cycle progression, and Hsp90 regulates the levels of the LIM kinase proteins by promoting their homo-dimerisation and trans-phosphorylation.