Laurence Ettwiller

TL;DR: A large operational analysis to chart the distribution of gene regulatory activities along the mouse genome, using hundreds of insertions of a regulatory sensor finds that enhancers distribute their activities along broad regions and not in a gene-centric manner, defining large regulatory domains.

TL;DR: A novel and unexpected activity of the proneural gene Ascl1 is identified, and a direct molecular link between the phase of expansion of neural progenitors and the subsequent phases of cell cycle exit and neuronal differentiation is revealed.

TL;DR: Three main areas in comparative genomics have recently shown important developments: whole-genome alignment, gene prediction and regulatory-region prediction, which improves the methods of deciphering long genomic sequences and uncovering what lies hidden in them.

TL;DR: It is shown that mutagenic damage accounts for the majority of the erroneous identification of variants with low to moderate frequency and signatures of damage in most sequencing data sets in widely used resources, establishing damage as a pervasive cause of sequencing errors.

TL;DR: It is shown that NFIX has a major role in the induction of quiescence in cultured NSCs and Transcript profiling of NS cells overexpressing or silenced for Nfix and the phenotypic analysis of the hippocampus of Nfix mutant mice suggest that NFix controls the quiescent state by regulating the interactions of N SCs with their microenvironment.