O
Osamu Minowa
Researcher at Japanese Foundation for Cancer Research
Publications - 46
Citations - 8582
Osamu Minowa is an academic researcher from Japanese Foundation for Cancer Research. The author has contributed to research in topics: Mutant & Receptor. The author has an hindex of 33, co-authored 46 publications receiving 8219 citations. Previous affiliations of Osamu Minowa include Japan Society for the Promotion of Science.
Papers
More filters
Journal ArticleDOI
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Kei Tobiume,Atsushi Matsuzawa,Takumi Takahashi,Hideki Nishitoh,Kei Ichi Morita,Kohsuke Takeda,Osamu Minowa,Kohei Miyazono,Tetsuo Noda,Hidenori Ichijo +9 more
TL;DR: It is shown that by deleting ASK1 in mice, TNF‐ and H2O2‐induced sustained activations of JNK and p38 are lost inASK1−/− embryonic fibroblasts, and that ASK 1−-/− cells are resistant to TNF- and H1N1‐induced apoptosis.
Journal ArticleDOI
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
TL;DR: Results indicate that Flt-1 without tyrosine kinase domain is sufficient to allow embryonic development with normal angiogenesis, and that a receptor tyrosin kinase plays a main biological role as a ligand-binding molecule.
Journal ArticleDOI
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
Yoshihiko Uehara,Osamu Minowa,Chisato Mori,Kohei Shiota,Junko Kuno,Tetsuo Noda,Naomi Kitamura +6 more
TL;DR: In this article, the authors found that homozygous mutant embryos have severely impaired placentas with markedly reduced numbers of labyrinthine trophoblast cells, and die before birth, suggesting that HGF/SF is an essential mediator of mesenchyme-trophoblastic epithelia interaction required for placental organogenesis.
Journal ArticleDOI
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
Mutsuo Matsumoto,Mutsuo Matsumoto,Toshiyuki Nakagawa,Toshiyuki Nakagawa,Takafumi Inoue,Eiichiro Nagata,Kanta Tanaka,Hiroshi Takano,Osamu Minowa,Junko Kuno,Shin Ichi Sakakibara,Shin Ichi Sakakibara,Maki K. Yamada,Hiroyuki Yoneshima,Atsushi Miyawaki,Yasuo Fukuuchi,Teiichi Furuichi,Hideyuki Okano,Hideyuki Okano,Katsuhiko Mikoshiba,Tetsuo Noda +20 more
TL;DR: It is reported that most IP3R1-deficient mice generated by gene targeting die in utero, and born animals have severe ataxia and tonic or tonic-clonic seizures and die by the weaning period and an electroencephalogram showed that they suffer from epilepsy.
Journal ArticleDOI
BMP type II receptor is required for gastrulation and early development of mouse embryos.
Hideyuki Beppu,Masahiro Kawabata,Toshiaki Hamamoto,Anna Chytil,Osamu Minowa,Tetsuo Noda,Tetsuo Noda,Kohei Miyazono +7 more
TL;DR: The results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development.