H
Hiroshi Takano
Researcher at Japanese Foundation for Cancer Research
Publications - 22
Citations - 3264
Hiroshi Takano is an academic researcher from Japanese Foundation for Cancer Research. The author has contributed to research in topics: Cellular differentiation & Hippocampal formation. The author has an hindex of 15, co-authored 21 publications receiving 3062 citations. Previous affiliations of Hiroshi Takano include Kyoto University & Tohoku University.
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Journal ArticleDOI
Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
Mitinori Saitou,Mikio Furuse,Hiroyuki Sasaki,Jörg-Dieter Schulzke,Michael Fromm,Hiroshi Takano,Tetsuo Noda,Shoichiro Tsukita +7 more
TL;DR: The generation and analysis of mice carrying a null mutation in the occludin gene suggested that the functions of TJs as well as occlUDin are more complex than previously supposed.
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Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions
Mitinori Saitou,Kazushi Fujimoto,Yoshinori Doi,Masahiko Itoh,Toyoshi Fujimoto,Mikio Furuse,Hiroshi Takano,Tetsuo Noda,Shoichiro Tsukita +8 more
TL;DR: Findings indicate that there are as yet unidentified TJ integral membrane protein(s) which can form strand structures, recruit ZO-1, and function as a barrier without occludin.
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Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
Mutsuo Matsumoto,Mutsuo Matsumoto,Toshiyuki Nakagawa,Toshiyuki Nakagawa,Takafumi Inoue,Eiichiro Nagata,Kanta Tanaka,Hiroshi Takano,Osamu Minowa,Junko Kuno,Shin Ichi Sakakibara,Shin Ichi Sakakibara,Maki K. Yamada,Hiroyuki Yoneshima,Atsushi Miyawaki,Yasuo Fukuuchi,Teiichi Furuichi,Hideyuki Okano,Hideyuki Okano,Katsuhiko Mikoshiba,Tetsuo Noda +20 more
TL;DR: It is reported that most IP3R1-deficient mice generated by gene targeting die in utero, and born animals have severe ataxia and tonic or tonic-clonic seizures and die by the weaning period and an electroencephalogram showed that they suffer from epilepsy.
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The RNA-binding protein HuD regulates neuronal cell identity and maturation
Wado Akamatsu,Hiroaki Fujihara,Takayuki Mitsuhashi,Masato Yano,Shinsuke Shibata,Yoshika Hayakawa,Yoshika Hayakawa,Hirotaka James Okano,Shin Ichi Sakakibara,Hiroshi Takano,Toshiya Takano,Takao Takahashi,Tetsuo Noda,Hideyuki Okano +13 more
TL;DR: The results suggest that HuD is required at multiple points during neuronal development, including negative regulation of proliferative activity and neuronal cell-fate acquisition of neural stem/progenitor cells.
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Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor
Masaru Niki,Hitoshi Okada,Hiroshi Takano,Junko Kuno,Kenzaburo Tani,Hitoshi Hibino,Shigetaka Asano,Yoshiaki Ito,Masanobu Satake,Tetsuo Noda +9 more
TL;DR: Results indicate that the two subunits function together as a heterodimeric PEBP2/CBF in vivo and that PEBP 2/ CBF plays an essential role in the development of definitive hematopoiesis.