Otto Mehls

TL;DR: Investigation of the long-term renoprotective effect of intensified blood-pressure control among children who were receiving a fixed high dose of an angiotensin-converting-enzyme (ACE) inhibitor revealed a substantial benefit with respect to renal function among children with chronic kidney disease.

TL;DR: Young adults with childhood-onset CRF have a high prevalence of arteriopathy associated with indicators of microinflammation, hyperparathyroidism, calcium-phosphate overload, and hyperhomocysteinemia but not traditional atherogenic risk factors.

TL;DR: Morphological and functional measures of large arteries should be normalized to take account of changes during adolescence and skewed distributions, as relative body mass, systolic blood pressure and/or pulse pressure are determinants of IMT and elasticity.

TL;DR: Gene mutations that have dominant inheritance and cause RHD, urinary tract anomalies, and defined extrarenal symptoms have been identified in TCF2, PAX2, EYA1, SIX1, and SALL1; it is interesting that a Six1 sequence variant was identified in two siblings with renal-coloboma syndrome as a result of a PAX2 mutation, suggesting an oligogenic inheritance.

TL;DR: Investigation of the pharmacokinetic (PK)/pharmacodynamic relationship of total and free MPA and PK values for the assessment of an individual's MPA PK parameters indicates that therapeutic drug monitoring of MPA has the potential for optimization of MMF efficacy in this patient population by steering patients away from the low values of M PA PK variables that are associated with an increased rejection risk.